Them: Maldives Beach

BSMLS2BCDEF: Glycosaminoglycans and Proteoglycans

Smoking causes intervertebral disc degeneration by 
1️⃣ Death of cartilage end plate (CEP) cells 
2️⃣ Destruction of type II collagen
3️⃣ Destruction of proteoglycans

Occurs in smokers AND passive smokers
 
Stopping smoking does NOT cause disc regeneration.

sciencedirect.com/science/articl…

so excited for proteoglycans GRC that we (Mia Huang 黃雪兒) wrote a mini-review about them! techniques to evaluate GAGs and core proteins, and methods to produce defined materials to piece apart how their fine structure impacts interactions! doi.org/10.1152/ajpcel…

Ready to attend the first in person UK proteoglycans meeting! UKProteoglycans

Well... it's official! My K01 was awarded by the NIDDK. Resubmitting during the pandemic was complicated but with the support of my family, friends, and mentors, we did it 😅

Proteoglycans are absolutely fascinating - can't wait to explore them further in hematopoietic injury!

#osteoarthritis pathophysiology includes increase in articular cartilage water content, decrease in proteoglycans, and disorganization and disorientation of collagen

#orthotwitter #MScUCL

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A blood vessel in murine🐁 heart🫀. WGA (🟢) binds proteoglycans, which are especially abundant in cell membranes. Thus WGA outlines cells’ borders. Nuclei are in 🔵 and 🔴 is for Parkin, protein crucial for mitophagy. However, we don’t see it a lot here.

Leica Microsystems

Super proud of our HS intern Nat and her great presentation today! 🥳 Natalia has been diving headfirst into the complex world of proteoglycans and click chemistry during her #summeratScripps with us in the ⁦Mia Huang 黃雪兒⁩ lab ⭐️

Kuru ve olgun cilt için; Lipo Proteoglycans ampuller!🔥
Doğal kaynaklı lipozomal proteoglikanlar içeren Lipo Proteoglycans ampuller, kolajen üretimini uyarır, cildinizin elastikiyetini arttırır ve sıkılaşmasını sağlar.

Finally at the BSMB ECR event in Manchester to talk about Adamts and proteoglycans! So excited to meet some ECM young blood! BSMB Douglas Dyer

Anybody else think the carpet at #ORS2024 Convention Center looks like cartilage ECM proteoglycans? 🤔

The 2024 Proteoglycans Gordon Research Conference is open for applications! The premier meeting for this area and the one where the researchers get to talk about the best, as-yet-unpublished work. lnkd.in/eHTWrwqE .

Dear proteoglycan lovers, I am happy to announce the birth of Proteoglycan Research, a new open-access journal published by Wiley. This new journal is devoted to all research on proteoglycans, hyaluronan, sulfated-glycosaminoglycans, and related molecules. onlinelibrary.wiley.com/page/journal/2…

This figure shows that each load results in a different cellular response. Tensile loading increases aligned collagen I; compression increases proteoglycans (cartilage genes that bring water into the tissue); and shear loads increase lubricin at the surface

The SAGAG group on its way to the Harden conference on proteoglycans, Biochemical Society !

➡️ Brain’s extracellular space contains abundance of proteoglycans & hyaluronan, which provide a low-resistance hydraulic conduit that rapidly can expand & shrink during sleep-wake cycle. We describe this fluid system of brain, meets brain’s requisites to maintain homeostasis.

Really enjoyed my first Proteoglycans GRC Proteoglycans GRC 2022 A really welcoming crowd, great science, and I’ve certainly had worse conference food!

Proteoglycans meeting in Japan 29th September - 3rd October. More information and registration at the website: proteoglycans2019.com
Remember that BSMB offers bursaries to our members to attend any ECM related meetings around the world. Please apply bsmb.ac.uk/page/other-bur…

Meet Xylose (Xyl)! Found in plants, and , as reduced xylitol, in chewing gum, xylose is also the first glycan attached to the amino acids Ser/Thr and elaborated with GAGs to make proteoglycans. A star in the extracellular matrix.