Establish hemolysis - Low hemoglobin, high mcv( not always), high retic count ( compensatory increase in immature RBCs, low haptoglobin, raise in indirect bilirubin and high LDH.

Cold auto HA - Rx Rituximab for symptomatic anemia.
Could be cold agglutinin disease, paroxymal cold hemoglobinuria etc.
Just know the names and refer to a hematologist.

G6PD - Avoid foods and medicines known to cause hemolysis.

Hereditary spherocytosis - splenectomy ..

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Nwoke Abacha of Abuja Chocolate agar should not replace Blood agar, because you Will appreciate hemolysis of organisms more on Blood agar plates either from urine or swab samples. CA plate can be used if orgs like Neisseria are suspected when there are no visible growth on the previous plates used.

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Dr. Thomas Ichim I've. for many years, postulated, a blast injury induces hemolysis, evidence, blood shot eyes, no studies, nadda. 'A side effect of hydralazine which is an antihypertensive agent is the formation of anaemia and this has been attributed to chelation by this drug with iron.'

NephroPOCUS Amk_rage Eduardo R Argaiz Philippe Rola korbinhaycockmd Katie Wiskar Volume IS a prime culprit. You really don't need to VExUS or US at all (unless you have another reason to).

They're severely hypertensive, they ARE volume up. Period.

Other than like a stroke raising BP or hemolysis/TMA/GN, if they're hypertensive they are volume up.

At a particular temperature and break.

Another cause is G6PD deficiency. Patient will give you a history of ingesting some new food or medicine after which he develops severe jaundice.

There is a long list of causes of hemolysis but just keep these broad causes on your diff.

MARCH 2023 RECALL PICTURE TYPE

PICTURE

1 BETA HEMOLYSIS (total clearing)
2 APLHA HEMOLYSIS (Incomplete greening or browning) recall*
3 GAMMA HEMOLYSIS (no color change)

Table showing compatibility and mismatch ( major or minor) between different blood groups among donor and HSC Recipient.
It is crucial to choose compatible/ minor blood group mismatch donor to prevent hemolysis

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'Mild hemolysis detected in sample' huh

*looks up hemolysis* oH GODS FUCK

What a gifted speaker !!! ⁦Austin Kulasekararaj⁩ speaking about pathophysiology and clinical management of extravascular hemolysis in #PNHsm at #EHA2023

Dr. Thomas Ichim 'Ci reduced the elevated serum creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH).
Those, curiously, are the markers for .. hemolysis, lysis of red blood cells.

น่าซื้อไปเก็บเป็นที่ระลึกมาก เพราะไม่มีคนทำแล็ปที่ไหนซื้อไปใช้จริงแน่นอน🤣🤣🤣 เล่นเลเบลทั้งรูปทั้งตัวหนังสือไว้เต็มเพลทขนาดนี้ ถ้าจะดู hemolysis ของเชื้อก็บังอีก5555555555555555555555555555 แต่ถ้าใส่ MacConkey หรือ Chocolate ก็ไม่กล้าเลเบลทับหน้าเซ็นคูอยู่ดีนี่เนอะ😂

Create an if...then statement involves creating a cognitive loop to help you recognize the concept in the future.

Ex: If I see low haptoglobin, then think intravascular hemolysis.

The if/then statement will be created after you read the NBME explanation.

Ideal But CA also shows hemolysis. I think the reason behind it is to reduce waiting time of culturing for another 24 hours if Neisseria failed to grow

'anion gap w/in range w/ hypoalbuminemia (correction suggestion)'
'mild hemolysis, may be falsely elevated, redraw if clinically warranted'
'platelet clumps present'

'here, have some atarax'

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Today at #EHA2023 , we presented Phase III results for our investigational, Factor D inhibitor as an add-on to C5 inhibition for patients with #PNH experiencing clinically significant extravascular hemolysis. Read more: spr.ly/6011OLXCf

Adrian H Jesse brodkin Dr. Jari Ylanne, a filamin expert in Finland, agrees that FLNA is not found in blood plasma or serum.

It’s intracellular, thus would be centrifuged down with all the cells and discarded.

An improper blood prep, storage (freeze/thaw) or hemolysis would have cellular debris.

Is an option.

Last thing but the most important one.

All patients who have chronic hemolysis will consume folic acid and will become deficient. Keep them on low dose folate replacement. Tab Folic acid 5 mg od life long.

This is the easiest approach i could give you guys.

Medicine residents what to do with hemolytic anemia😵‍💫

A simple approach to make your life easy peasy.

No. 1 - establish hemolysis
No. 2 - determine the type and cause
No. 3- treat it

Lets discuss 1 by 1.

Alexander Röth presentated data from COMMODORE2 showing crovalimab was non-inferior to eculizumab in terms of hemolysis control, and adverse events in tx naive #PNH patients. Drug is given as self SC injection 4 weekly. #EHA2023 #BMFsm 2/3👇