From our recent bioRxiv paper: Watching an antibody find the bound state through a maze of glycans. This simulation is for a glycan-binding broadly HIV-1 neutralizing antibody. Experimental evidence suggests the antibody 'learns' to do this as it matures.

Excited that this is now out in the world! If you're interested in glycans and viruses (or if you'd like a light night time read), feel free to indulge ☺️

Over the holidays I made a new lab logo, it is based on a Canadian postage stamp, using the symbolic nomenclature for glycans to embed the TB cell wall...

Universal Donor Blood Significantly Closer Thanks to Enzymes Found in Gut Bacteria

Enzymes from gut bacteria open a new path to universal donor blood by efficiently clearing glycans from red blood cells. Learn more: ow.ly/GE3g50RstR6

Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels | bioRxiv

biorxiv.org/content/10.110…

glycosyphosphatidylinositol
phosphatidylinositol glycan class a

Our 2023 Dec issue bit.ly/2N9R8Es reviews malaria merozoite invasion, trypanosome & complement, Trichomonas persistent infection, schistosomiasis hotspot, light pollution & aquatic parasites, artemisinin resistance, protozoan population dynamics, tick salivary glycans...

Is the spike protein of KP.2 adorned with additional glycan chains? open.substack.com/pub/voiceforsc…

Recently one of our grad students, Ariana Stratton (Ariana), was selected for the Merck Rising Stars in Measurement Science Symposium in NJ! She showed her latest research imaging glycans! #YouGlyCanDoIt #ImagingMS

Yinz it's happening. My dream of opening my own lab is coming true as the Guseman lab will be opening at UC San Diego in Jan '24! We will be studying the biophysical basis of protein glycan recognition & mechanism(s) of glycan targeting antivirals at UCSD Chem Biochem 1/ many

And while we discussed glycan-Siglec interactions, we also had fun, saw the Guggenheim and shared time together ✨ grateful for all the opportunities and experiences 🤍🩵

Unlock the secret to unparalleled health 🗝️✨ Discover the wonders of Glycans in our nutritional supplements and join a community ready to thrive! Ready for a change? #GlycanRevolution #HealthyLiving

Happy Wednesday vibes, everyone! 😊 Did you know about the magic of Glycans for your health? As someone who loves helping others achieve their best health, I'm all about sharing this goldmine. Join us in embracing a healthier lifestyle. Let's thrive together! #WellnessWins

Proud to contribute to an awesome project analyzing LLSM data.
Spatial #glycan rearrangement.
doi.org/10.1101/2023.1…
leconte ludovic, M. Shafaq-Zadah,E. Dransart, Christian Wunder,Salamero jean,Johannes team Institut Curie Centre Inria de l'Université de Rennes France-BioImaging Research Infrastructure 3i #bioimageanalysis

📅 This week, GlycanTrigger team is meeting in Leiden for our 2nd General Assembly Meeting
🔬The project is on a mission to find a way to intercept chronic inflammation by studying how changes in glycans impact the initiation of the inflammatory process
🚀Stay tuned!

Sifting through some of the recent H5N1 samples uploaded. Immediately mutes like N110S in the HA protein stand out, impacting binding with sialic acids of cell-surface glycan receptors found in humans. Just one of many fitness advantages that will help it to infect human hosts.

phew 😅
*correction*
#notrocketscienceTRIVIA

that's what I get for tweeting during trivia

we broke our streak last night 😅 and lost but we're still enjoying the funds from previous wins. It's all about fun with friends.

Go team Pep-tiddy-glycans!

🌟Wrapping up day 1 of our 2nd GlycanTrigger General Assembly Meeting in Leiden!💭It is been a productive day with many fruitful discussions🙌WP1, 3, 4 and 6 had the opportunity to report 2023 activities and the action plan for 2024, and discuss their latest research findings🔍

4) O-Glycosylation sites

The Proximal Origin authors first noticed the presence of potential O-glycosylation sites leading to the FCS. These are simply Serine or Threonine residues. They don't always attach to glycans, but one thing that increases the odds is a nearby Proline.