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Excited to share our latest manuscript, "The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9," now published in Leukemia Journal. nature.com/articles/s4137… Here's a brief synopsis 1/n

Hematopoiesis/Leukemia fans, check out our updated program for our Fusion Conferences Myeloid Malignancies Conference in Crete! Added a new Keynote (IdoAmitLab) and new additional speakers...Early Bird Registration is coming up, December 12th! fusion-conferences.com/conference/180

Overwhelmed by all of the exciting advancements surrounding chromatin modifiers in AML? Do you find it hard to keep track of all the new menin inhibitors? Well good news, we’ve just published the perfect review for you in STEM CELLS Translational Medicine academic.oup.com/stcltm/advance… Kira Gritsman

NEW-Tranexamic acid did not prevent bleeding in patients with haematological malignancies and severe thrombocytopenia compared to placebo: results from the randomised, double-blind, parallel, phase 3, TREATT trial thelancet.com/journals/lanha…

Cancer screening is the best way to catch cancer before symptoms appear and when it’s easier to treat. It’s #CancerScreenWeek—a reminder to talk to your doctor to learn about what cancer screening is recommended for you. Learn more: go.nih.gov/LUvTRWH

A nice commentary in this issue of Blood Journal for our paper looking at the role of #ClonalHematopoiesis in #TBD from Chris Reilly and Mikko Myllymäki - a somatic symphony; telomeres and CH! ashpublications.org/blood/article/… Fernanda Gutierrez-Rodrigues Sharon A. Savage, M.D. ashpublications.org/blood/article/…

Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance dlvr.it/TGccwD

Dr Louks, we support you. Last week, Cambridge PhD student Dr Ally Louks published this photo on X to celebrate passing her viva with no corrections. Her tweet went viral, attracting over 100 million views 🧵

Now online in Cancer Discovery: Discovery of BBO-8520, a First-in-Class Direct & Covalent Dual Inhibitor of GTP-Bound (ON) & GDP-Bound (OFF) KRAS G12C - by Anna Maciag, James Stice, Bin Wang, Frank McCormick, Pedro Beltran, et al. doi.org/10.1158/2159-8… Frederick National Laboratory BridgeBio Pharma

Preprint alert: If you missed Rebecca Ling 's talk at #ASH24 about the role of LIN28B in lymphopoiesis and infant ALL, please read about it online. All feedback welcome! Oxford Cancer Department of Paediatrics MRC WIMM biorxiv.org/content/10.110…

A View of Myeloid Transformation through the Hallmarks of Cancer. bit.ly/3Zt3q21 #ASH24

Bollywood themed ASH President’s Reception party in San Diego, everyone had an amazing time on the dance floor! #ASH24 #Bollywood

Alternative splicing that is controlled by the cotranscriptional splicing complex may be therapeutically tractable in high-risk B-ALL. ow.ly/8e2b50Um9of #lymphoidneoplasia

Excited to have our timely review on therapeutic interventions and early clinical trials in CH just out! Thank you to all the co-authors for a close collaboration and effort! ⁦British Journal of Haematology⁩, ⁦⁦Montefiore Health System⁩ ⁦EinsteinSCI⁩ onlinelibrary.wiley.com/doi/10.1111/bj…

Myeloid effector cells in cancer dlvr.it/TGkhFv

bioRxiv paper here: Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients biorxiv.org/content/10.110…

We are thrilled to share our new preprint around oncoprotein degradation in vivo —a fantastic collaboration with our friends in Salamanca Santamaria’s Lab Centro de Investigación del Cáncer (CSIC-USAL)! 😃 IRB Barcelona #TPD #KRAS 👇 biorxiv.org/content/10.110…

Online Now: Cytokines in cancer dlvr.it/TGqY7Z

Hugues de The and I want to remind you that nothing has cured more cancer patients than conventional chemotherapy!!! Think you understand how it selectively kills cancer cells so well? Take a look inside. Dana-Farber Dana-Farber News

Excited to share our new paper in Molecular Cell! We’ve developed TurboCas, a powerful new CRISPR-based proximity labeling tool that lets us pinpoint the proteins regulating gene expression at specific genomic loci. Check out what we discovered: cell.com/molecular-cell…