Yesterday, at the International AIDS Conference (#AIDS2024) in Munich, we got one of those thrilling moments you hope for when attending a scientific conference -- but don't usually get! Here's what happened. Linda-Gail Bekker Moupali Das, MD, MPH blogs.jwatch.org/hiv-id-observa…

It's here! 100th #Breakpoints Episode: Drs. Jeffrey Pearson & Jason Pogue join Dr. Jeannette Bouchard as they take on all things tetracyclines. Do not miss this one! This podcast was supported by an unrestricted grant from Paratek Pharmaceuticals Inc. 🎧 sidp.pinecast.co

💩 additional evidence that cefepime causes more CDiff than piptazo 💩theoretically piptazo has anaerobic coverage so you might assume that it should cause more CDiff.. but it doesn't 💩 this is why we need EBM, not handwaving about saving the anaerobes sciencedirect.com/science/articl…

If you’re wondering, “But wait, how do I know the pre-test probability for bacteremia in common infectious diseases?” Well, Valeria Fabre covers some of these in this must-read scoping review! academic.oup.com/cid/article/71…

It's your favorite post of the month- the articles of interest for August! With a few from June and July 😊🦠

Learned something new today 😳

Me on ICU rounds when someone says we can’t use linezolid because the patient is on an SSRI

Clinical Infectious Diseases 👏👏👏

More is not always better. Adding vancomycin to cefazolin as surgical prophylaxis in patients undergoing arthroplasty does not improve outcomes in patients not known to be MRSA colonized. Outcomes WORSE for knee arthroplasty. Just don't. nejm.org/doi/10.1056/NE… #IDWeek2024

Kate DeSear crushing it & getting everyone talking about, is this really AKI when it comes to vanco + pip/tazo? And coining the term fake-KI 🤩 Her key lesson…we probably don’t need vanco (or pip/tazo) for most patients! #IDWeek2024 #SIDP2024

Good board review on Candida treatment. #IDWeek2024

1/2 Dr. Shruti Gohil UCI Health presented INSPIRE data on intra-abdominal infections (IAIs) at #IDWeek2024. IAIs involve diverse organs/spaces. Yet, only 1% (+) for MRSA and another 1% (+) for Pseudomonas, despite 63% of patients getting empiric broad-spectrum abx treatment.

Bug Pharmacist 💊🧫 Tim Gauthier Linezolid is superior (not just non inferior) to vancomycin for SSTI. pubmed.ncbi.nlm.nih.gov/34143418/

MYCOPLASMA PNEUMONIAE This cheeky little intracellular bacteria seems to be up to mischief with kids in the USA at the moment A quick thread on this bug, what's going on, and what to do (or not do!) about it 1/🧵

journals.asm.org/doi/10.1128/aa… Nice!!!

Switching to an oral azole (fluconazole or voriconazole) is moderately recommended after 5 or more days of echinocandin treatment in patients meeting the following criteria 👇 #idxposts

Effects of cancer therapy on AMR Cisplatin➡️cross-resistance to FQ (target bacterial DNA) Methotrexate➡️dihydrofolate reductase mutations➡️co-select for β-lactams/AG/fosfo resistance Anthracyclines➡️efflux pump expression Etoposide➡️oxidative stress➡️gyrA mutations

Still using clindamycin for necrotizing SSTIs? Time to consider the switch to linezolid: 🦠Similar toxin inhibition 💩 Better AE profile (⬇️ C. Diff ) 2 for 1: no vancomycin (🙅‍♀️ AKI) 🧫No ⬆️ resistance ⁦Michael Gottlieb⁩ ⁦AnnalsofEM⁩ sciencedirect.com/science/articl…

🆕🔥 Review Article Pharmacotherapy by many 🌟s SE Research Group P. Brandon Bookstaver Chris Bland A review of antibiotic safety in pregnancy —2025 update #IDXposts accpjournals.onlinelibrary.wiley.com/doi/full/10.10…