Last week marked 60 years since the discovery of Epstein-Barr virus, the most common viral infection in humans. An interesting podcast episode from The Guardian recently delved into how understanding #EBV might help us prevent & treat autoimmune diseases & cancer. Notably, multiple…

'NOD2 susceptibility variants analysis can help tailor the patients’ approach; its clinical impact may be greater than currently recognized. By using NOD2 as a genomic biomarker, we can predict disease location, phenotype, and risk of surgery.'

academic.oup.com/ibdjournal/adv…

#crohns

EEN is one of the best treatment options available to people with #CrohnsDisease .

.Dale Lee, Kimberly Braly & colleagues found a whole-foods smoothie mimics commercial oral milkshakes for inducing clinical & biochemical remission in children with active CD.

[🧵 inside]

A Swiss team has discovered an enzyme called cyclic GMP-AMP synthase (cGAS) & is studying whether manipulation of it & its chemical 'control switch' could help control #IBD and other immune-mediated diseases.

sciencealert.com/scientists-fin…

#crohns #crohns disease #ulcerativecolitis

Join our peer-support meeting for young adult patients with #IBD on March 28th! This will be a discussion on dealing with treatment burnout with at 8PM EST/ 5PM PST!

To register or for more information visit ccyanetwork.org/meetings!

#Crohns #Colitis

Bacterial proteases are involved in Crohn’s disease.

.Ken Croitoru shares recent data from Verdu Lab supporting that specific microbial proteolytic signatures can be targeted for interventions in patients with CD, preferably at an early stage of the disease

#GMFH2024

Outstanding story by Wale Bamidele on how pro-inflammatory cytokine IL-21 metabolically rewires Regulatory T-cells rendering them pathogenic in the inflamed intestine, w/ potential implications for novel #IBD therapies William Faubion Mayo Clinic Gastroenterology & Hepatology

authors.elsevier.com/c/1ioJa3mEmjNLx

🚨🚨I'm delighted to present our new work, where we aimed to understand why antibiotic use is a risk factor for development of inflammatory bowel diseases (IBD). Yes, MUCUS will be involved! A 🧵/1

📢Very exciting work with focus on regulation of ILC2 in #IBD validating our prior findings that dietary #fibre inulin can promote inflammation and expanding on their prior studies to show the role of microbial metabolites mediating host responses to #diet
#microbiome

'Our findings underscore the importance of focusing on microbial functions—not taxa—contributing to IBDs and that some diet-mediated functions can oppose those that promote disease.'

cell.com/cell-host-micr…

#ibd #crohns #microbiome #fiber #microbe #mucus #bacteria #colitis

Did you know that patients & caregivers can get paid to advance research while also supporting Propel A Cure for Crohn’s Disease?

Sign up today & share your voice through our trusted referral program 👉 tinyurl.com/RVP-propel

#IBD #Crohnsdisease

Thank you for your generous grant!
Propel a Cure for Crohn's works to accelerate the treatment of the disease by taking courageous approaches beyond the status quo.
We think alike, we are very honored !

📣 Towards patient-centricity: future clinical trials must prioritize patients’ needs ‼️
#ClinicalResearch

Virginia Solitano Vipul Jairath MBChB DPhil
Western University

Elevated levels of the protein SLAMF7 drives pathogenic inflammation common in rheumatoid arthritis and could also be a source of inflammation in #CrohnsDisease and #COVID19 .

Check out the 2022 Science Immunology study: scim.ag/6d5

Just two weeks left to apply for the Early Career Catalyst Awards! Funding will support two early career investigators whose basic & translational/therapeutic research has the potential to improve the lives of people with #IBD . Apply by March 29. krfoundation.org/grants/funding…

🚨This is a really important and timely study, showing the effects of antibiotics on the colonic mucus layer through its effect on the microbiota. Look out for our study which will drop soon and expand on the ABX-IBD link. Congratulation Bjo:rn Schro:der and team!!