Open Source Malaria
@o_s_m
Open Source Malaria - finding new medicines - join in!
ID: 342023138
http://opensourcemalaria.org 25-07-2011 10:36:33
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We need to remember why we fund biomedical research - for the public good. A reboot is possible say my Drugs for Neglected Diseases initiative colleagues. We Structural Genomics Consortium (SGC) obviously agree. ViMI #READDI nature.com/articles/d4158…
FYI we wuz cited :) Open Source Malaria Matthew Todd (team just down the road did you have a pint with 'em?) MedChemProf biorxiv.org/content/10.110…
Delighted to have Matthew Todd join Structural Genomics Consortium (SGC) to lead our new “open chemistry network” initiative. Any chemists who want to help generate #openscience #chemicalprobes for cool human proteins, get in contact with Mat! thesgc.org/sgc-open-chemi…
Are you an Open Source Malaria contributor? Want to spread the word? Download the logo for your own talks, and print/display the poster in your lab/office to highlight what we're doing in #openscience drug discovery for the treatment of #malaria. See github.com/OpenSourceMala…
From ACS's virtual issue go.acs.org/YB in recognition of #WorldMalariaDay Research by Matthew Todd & >50 authors Open Source Malaria New antimalarials are discovered using an “open source” approach that discloses data in real time and eschews secrecy go.acs.org/YC
Awesomely great that @ersiliaio were awarded $ from Rosetrees Trust to work with us on #AI #machinelearning predictions for Open Source Malaria #malaria Series 4. @TuronGemma and @mduranfrigola will predict, and we (Edwin Tse) will make/buy github.com/OpenSourceMala… Medicines for Malaria Venture (MMV) #openscience
Updated scheme on original hit OSM-S-106 data in Open Source Malaria Series 3, bottom of this page github.com/OpenSourceMala…. Such good data. A slug of new data on mechanism of action coming v soon - just collecting it together. #malaria #openscience
And a new SAR diagram on OSM-S-106 Open Source Malaria Series 3 bringing together key comparisons, near bottom of github.com/OpenSourceMala…. #malaria #openscience One great compound, so many cliffs.
The #KigaliDeclaration on #NTDs launched at the #Kigalisummit taarifa.rw/kigali-declara… Important high level support for new research for the world's most neglected and terrible diseases. Declaration can be read on the Uniting to Combat Neglected Tropical Diseases website unitingtocombatntds.org/kigali-declara… Drugs for Neglected Diseases initiative
New Series 4 potency data on compounds designed by @ersiliaio, including new 77 nM hit. github.com/OpenSourceMala… #malaria #openscience Medicines for Malaria Venture (MMV) Next: new round of prediction and synthesis. Maybe mic clearance on OSM-LO-72? Edwin Tse Matthew Todd
Generous contribution of molecules to Open Source Malaria from Rahman S Z Saleem with testing courtesy of Medicines for Malaria Venture (MMV) github.com/OpenSourceMala… Structurally similar to Series 1 (10.1021/acscentsci.6b00086)(with the same PAINS risk), unfortunately all inactive. #malaria #openscience
Fun with #GPT4 - ping Medicines for Malaria Venture (MMV) Malaria No More Christopher Southan Chris Swain Edwin Tse I see @AI_drugs MedChemProf #malaria #medchem
The paper describing the mechanism of action of Open Source Malaria series 3. The hit, discovered by a GSK screen, had been explored by many in Open Source Malaria. We parked it. Now spectacularly re-awoken by beautiful work by Leann Tilley @ElizabethWinze1 and many others. #malaria
Lab meeting on how to set up GitHub for lab projects and how we use repositories. This is video 1, the basics. More coming on Issues and the Wiki. We've used Github for years in Open Source Malaria Open Source Mycetoma and now across Structural Genomics Consortium (SGC) and READDI-AViDD. youtube.com/watch?v=25C7it… #openscience
