Nailed it!

#OTD 1922 RA Fisher publishes 'On the Mathematical Foundations of Theoretical Statistics'. He first read it to RSS Royal Statistical Society on 17 Nov 1921. It ushered in modern mathematical statistics & marked a seismic shift in statistics which until then lacked a unifying structure. 1/6

I've written about race, genetic ancestry, analyses of large biobanks, and human history

gusevlab.org/projects/hsq/#…

I'll summarize the key points here 🧵:

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

Our new multi-ancestry PRS method MUSSEL has been published on Cell Genomics. It uses a Bayesian multi-variate spike and slab prior plus super learner to improve PRS performances. Huge congratulations to Jin Jin ,Jianan Zhan , Jingning, Nilanjan Chatterjee and all! Cancer Epi & Genetics

Congratulations Jin Jin for leading such an incredible effort! Grateful for the contributions by our amazing collaborators who gave us data and their wisdom!

Cell Genomics Nilanjan Chatterjee Jianan Zhan Haoyu Zhang Ruzhang Zhao reached word limit... also huge thanks to Gen for all your help Genevieve Wojcik, PhD MHS!

Today (April 2nd) marks four years since the untimely passing of James Taylor (James Taylor), Professor of Biology and Computer Science at Johns Hopkins University and one of the founders of Galaxy. To honor James, we have established the James TaylorFoundation for open-science (jxtxfoundation.org).

Register today for our April 8 seminar 'Challenges in Deep Learning,' with Distinguished Bloomberg Professor Rama Chellappa. This seminar is co-hosted with the Johns Hopkins Bloomberg School of Public Health initiative PHAISE (Public Health + AI Strategic Endeavors). Sign up here: publichealth.jhu.edu/events/2024/ph…

Glad to see this in print now. New method to perform cross tissue TWAS. Spearheaded by the brilliant Brian (Xinyu) Guo. Check out the method: github.com/Thewhey-Brian/…
Nilanjan Chatterjee Cancer Epi & Genetics

Back to Hiroshima for the Scientific Advisory meeting of the Radiation Effect Research Foundation. I always like going to the peace memorial park in the wee hours and absorb the solemness of the place. The mission of RERF is so critical for survivors, their children n humanity.

This #WomensHistoryMonth Johns Hopkins Bloomberg School of Public Health faculty were asked to name women who have made important contributions to their #publichealth field. Nilanjan Chatterjee highlighted Nan M. Laird, PhD. Learn more about Dr. Laird and the other women celebrated, here ⬇ publichealth.jhu.edu/2024/celebrati…

Very excited to share out recent work on Indian evolutionary history led by Elise Kerdoncuff & Laurits Skov. Many surprises (e.g., archaic ancestry in India) and some clarifications (e.g. source of Iranian-farmer ancestry related to Sarazm) and timing of OOA in India. More details👇

Excited to share our review paper in Cell! With Sasha Gusev Sohini Ramachandran Yang I Li we discuss the genetic and molecular architecture of human traits, future opportunities and challenges and ways forward.

authors.elsevier.com/a/1igrbL7PXqPfU

In conclusion, there is no methodological limitation for running powerful/rigorous GWAS in admixed populations! Please do not disregard admixed data from your association studies.

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Ziqiao Wang Nilanjan Chatterjee Pradeep Natarajan Congrats again, Ziqiao Wang !