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🤩 Congratulations to our very own Yale School of Medicine Prof. HHMI Investigator and ISSCR President Valentina Greco on being named as one of 50 "Scientists that Inspire" - we can definitely attest to that! cell.com/news-do/50-ins…

Thrilled to announce that my back-to-back co-first author papers are out today in nature! We present a long-term clinical study in patients and a preclinical study in mice, demonstrating the unexpected role of type-2 immunity in sustaining durable CAR T and ICB immunotherapies!

7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

Thrilled to present Patho-DBiT out Cell A first-of-its-kind technology for spatial whole transcriptome sequencing of clinically archived FFPE tissues, mapping various large/small RNAs, alternative splicing, and genome-wide SNV, all at once from the same tissue section!

Check out the full agenda for #chromatin2024! We've got a packed schedule with incredible guest speakers and exciting talks on 3D genome architecture and nuclear topology in #cancer. Registration is FREE! See you in November 👉 bit.ly/chromatin-2024

New ENCODE Project preprint from the lab! Through CRISPR screens, we identify functional enhancers for neuropsychiatric disease risk genes in iPSC-derived neurons. We revealed an exciting allelic compensation effect (ACE) on transcription for the dosage-sensitive gene SIN3A.

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We are thrilled to share that our first paper from my new lab, Spateo (github.com/aristoteleo/sp…) for spatiotemporal modeling of molecular holograms, is now online in Cell: cell.com/cell/fulltext/…. Spateo is a comprehensive analytical framework for 3D whole-embryo spatiotemporal

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, Nature Communications, 4DNucleome, The 3D Genome, Human Genome Org, Network Science Society, @Emblebi, @MoGen_Grads

Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S

Huge congratulations to Shengyan on a successful defense!! Wishing you all the best in your next steps🥳🎉⭐️🎈

Call for Papers – Spatial Biology in BMC Methods! 🧬🔬 I am excited to serve as the Guest Editor for the Spatial Biology Collection in BMC Methods (BMC)! This special issue will focus on the latest advances in spatial omics, imaging mass spectrometry and more.

Evolution-guided protein design of IscB for persistent epigenome editing in vivo go.nature.com/44XVBph

NEW review article from Henikoff and Ahmad about emerging epigenomic mapping technologies to study chromatin regulation. Very comprehensive - great for beginners and experts alike! sciencedirect.com/science/articl…

Excited to share our work in Nature Methods! InterpolAI is a deep learning framework that uses optical flow to interpolate and restore missing or damaged biomedical images, allowing enhanced 3D maps across diverse imaging modalities. Read more: nature.com/articles/s4159…

If your stack of images is full of defects, don't panic! InterpolaAI, a deep learning-based optical flow method, will fix issue tears, photobleaching and sticking artifacts for improved 3D imaging. Read our paper in Nature Methods: nature.com/articles/s4159…

Excited to share our latest paper in Nature Genetics with Siyuan (Steven) Wang on the evolution of 3D genome organization in 🐁 models of #LungCancer and #PancreaticCancer. Kudos to Miao Liu Sherry Su! Yale Department of Genetics Yale Cancer Center Yale Cancer Biology Institute nature.com/articles/s4158…

In a recent Nature Genetics study, Yale Department of Genetics researchers create detailed #3D maps of cellular #genomes to help chart #cancer's progression from pre-cancerous to advanced disease, laying the groundwork for future treatments: bit.ly/47BvZ2U