Really enjoying #MetSoc2022 so far… Great to be abroad for the first time in 3 years and to be discussing all things #Metabolomics! There’s still time to see my poster about the metabolomic effects of bariatric surgery between 5 and 6.30pm today - no.382 in auditorium 3

Finally: causal estimates for adiposity & metabolomic traits at scale! Pleased to share the first large-scale comparison of conventional vs MR approaches in UK Biobank in The Lancet Reg Health-Europe sciencedirect.com/science/articl… Key takeaways:

Such a great cohort of MRC IEU PhD candidates, well done at #IGES22! Fernanda Morales, Ciarrah-Jane Barry, Helena Urquijo,Marina Vabistsevits, Andrei Constantinescu, Maddy Smith, Panagiota Pagoni, Genevieve Leyden. And Drs Nance and James Yarmolinsky

Fab few days in Paris at #IGES22 with a lovely bunch of people. Especially enjoyed presenting my reverse-MR work at the poster session this afternoon 🧬

Our results highlight the economic adversity experienced by those with a history of ACEs during the lockdown measures (job loss, furlough etc.) - few interventions currently target this group and lockdown may have exacerbated their needs. 3/3

📣 New paper out now in JAHA! 📣 We show that drinking alcohol during pregnancy is associated with a lower risk of hypertensive disorders of pregnancy (HDP) ... and explain why we *don't* think this reflects a true causal effect 🤰🍷 (1/4) ahajournals.org/doi/10.1161/JA…

We have another great talk this month in DEMON Network biomarkers working group. Maddy Smith and Hannah Compton will be telling us about Metabolomic signatures of genetic liability to Alzheimer's disease. Wed 10am BST.

New #OpenAccess paper published using Children of the 90s data: #SocioeconomicPosition & #AdverseChildhoodExperiences as risk factors for health-related #BehaviorChange & #EmploymentAdversity during #COVID19pandemic Maddy Smith published in BMC Series BMC bit.ly/PaperC2685

I'm glad to announce that our polygenic score-metabolite atlas has been published on eLife - the journal 🥳 This atlas contains associations between 125 PGS for complex traits and 249 NMR-derived metabolic traits from up to 83,004 individuals in the UK Biobank. elifesciences.org/articles/73951

Glad to see our study exploring the effect of COVID-19 on platelet function as a preprint! Link: biorxiv.org/content/10.110… 1/6

Our data note describing the inflammation proteomics dataset measured by Olink Proteomics in 9000 Children of the 90s participants is now out in WellcomeOpenResearch doi.org/10.12688/wellc… 1/3

PhD student Maddy Smith will be presenting her research about the long-term metabolomic effects of bariatric surgery, which uses samples from BBS participants, at the Molecular Epidemiology Group UK (MEG-UK) annual meeting in Edinburgh next week.

Enjoying sunny Edinburgh and the Molecular Epidemiology Group UK (MEG-UK) conference. Great talk from Emma Hazelwood on weight loss and colorectal cancer risk and Maddy Smith talking later about weight loss and the metabolome!

Excited to see this paper now published in JTH doi.org/10.1016/j.jtha…

Delighted to see our work on the metabolic features of genetic liability to type 2 diabetes and coronary artery disease published in eBioMedicine – The Lancet Discovery Science today! Joshua Bell @emmylooroll Caroline Bull Eleanor Sanderson george davey smith Michael V Holmes (he/him) thelancet.com/journals/ebiom…

We had a wonderful array of discussions today at our Standing up for Science workshop! Thank you for your expert insights and advice for ECRs Jack Stilgoe @profmarkmaslin Dr Roz Eggo Rachael Buchanan 💙 #NHSBlueHeart Anjana Ahuja Franca Davenport Prateek Buch also found where the Sky is Blue Institute of Physics Leonie Cooper AM senseaboutscience.org/voys/workshops/

I wrote a blog post about my experience attending and presenting at #EASD2023 this month! Read it here: ieureka.blogs.bristol.ac.uk/2023/10/25/eas…

Nice to see our paper out in Scientific Reports. We used data from two weight loss trials (By-Band-Sleeve and the Diabetes Remission Clinical Trial) to explore the effects on circulating proteins. nature.com/articles/s4159… 1/4