I am co-translational A must read review in Journal of Molecular Biology by Tora Lab lab sciencedirect.com/science/articl…

It’s official! MutS2 still doesn’t cut it. Congrats Esther Park and Beckmann Lab! embopress.org/doi/full/10.10…

Online Now: Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria dlvr.it/T19bmw

bioRxiv: Mechanism of chaperone coordination during cotranslational protein folding in bacteria dlvr.it/T1mPPk

We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.

Now out Molecular Cell sciencedirect.com/science/articl…

Scientists from the Hartl Department show that the protein #Urm1 protects other proteins in cellular stress situations by promoting phase separation. ❕Publication: cell.com/cell/fulltext/… ❕Press release: biochem.mpg.de/urm1-protects-… Cell Press

Together with the amazing Beckmann Lab, we have uncovered that tigecycline not only blocks A-site tRNA binding but also directly binds to the PTC on the human 55S mitoribosome. nature.com/articles/s4146…

Now online! Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1 dlvr.it/T8xY6Y

Now out NatureStructMolBiol nature.com/articles/s4159… 3 takeaways:

Authors including Jingdong Cheng report cryo-EM structures revealing how antibiotic tigecycline can also target human mitoribosome. nature.com/articles/s4146…

bioRxiv: H/ACA snoRNP guides ribosomal RNA subdomain folding in a satellite particle before joining the core 90S pre-ribosome dlvr.it/TCynHY

First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. Max Planck Institute of Biochemistry (MPIB) 👇👇👇

Very excited to share the structure and functional characterization of Clusterin, a key extracellular chaperone and apolipoprotein (ApoJ) linked to cancer, cardiovascular pathology and neurodegeneration. biorxiv.org/content/10.110…

Online Now: Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides dlvr.it/TFyBh5

Excited to see our LARP1 manuscript published at The EMBO Journal. We show that LARP1 directly binds non-translating ribosomes and TOP mRNAs. An excellent collaboration with the Jingdong Cheng lab! embopress.org/doi/full/10.10…

Online Now: Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes dlvr.it/TGGX7c

Online Now: Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching dlvr.it/TGXlng

m6A sites in the coding region trigger translation-dependent mRNA decay dlvr.it/TGfTnN