Many insights into gene regulation result from in-depth characterisation of model gene loci. We reviewed recent studies of the alpha-globin cluster and lesson learned about gene regulation & genome organisation: sciencedirect.com/science/articl…, with Rob Beagrie, Mira Kassouf & Doug Higgs

I’m very happy to share this Nature Reviews Genetics review in which Doug Higgs and I discuss the most recent insights into genome organisation, gene regulation and their relationship: nature.com/articles/s4157… #3Dgenome #generegulation

Out Today! Using our new method (scaRNA-seq) we found enhancers regulate PolII Recruitment and Initiation – rather than Pausing Molecular Cell Gene Regulation #GeneRegulation sciencedirect.com/science/articl…

Enhancers may cooperate synergistically to determine cell fate. Synergistic enhancers are defined by eRNA synthesis, depend on cell-specific TFs and differ form occupancy-defined superenhancers. Great collaboration with Graf & Söding labs. Finally out: doi.org/10.7554/eLife.…

Why are ultraconserved enhancer sequences ultraconserved? Our latest attempt to solve the mystery, led by Valentina Snetkova Here is the TL;DR thread (1/n) nature.com/articles/s4158…

Delighted to share my lab’s jdavieslab first big paper in nature! We’ve developed a new 3C technique called Micro Capture-C that can generate base pair resolution 3C data nature.com/articles/s4158…

Really happy to see our latest work out on bioRxiv. We used live-cell antibody staining to facilitate the study of alpha-globin transcriptional bursting dynamics throughout erythropoiesis and identified changes in transcriptional noise during differentiation. Check it out! ⬇️⬇️⬇️

Kicking off 2022 with my first senior #author research paper.The novelty lies in reimagining the use of a well-established #mESC #invitro system harnessing new technologies to serve genetic studies Hele Francis Rob Beagrie Dr Danuta Jeziorska (she/her) MRC WIMM PLOS One journals.plos.org/plosone/articl…

🚨Job Alert🚨 We’re hiring a postdoc to work on genetic diseases of chromatin! 🧬 🏫Come work with us at Centre for Human Genetics in the beautiful University of Oxford 🗓Closing 6 July 📨 More details at beagrielab.com/join Pls share and RT! #PostdocJobs #GeneticsJobs #genomics #cohesin

Have you ever made backwards DNA??? Brendan did - on purpose!! . Check out what happens to "vanilla" DNA in yeast and mouse cells. What do they do with DNA they've never seen before? #darkmatterproject strikes again ... courtesy of @bcamellato biorxiv.org/content/10.110…

Only one week left to apply for our postdoc position! If you're interested in human genetics, chromatin, and gene regulation then check it out! Informal inquiries always welcome

#Superenhancers function in an orientation dependent manner,challenging #enhancerbiology paradigm. Hele Francis josephblayney Maria C Suciu, PhD Caz Harrold Jim R. Hughes Damien Downes Marieke Oudelaar Nature Genetics Hannah Long James Davies Gene Regulation MRC WIMM biorxiv.org/content/10.110…

Our machine learning approach to peak calling "LanceOtron: a deep learning peak caller for genome sequencing experiments" has been published. If you want better peak calls and less false positives in your ChIP-Seq results, please give it a try! doi.org/10.1093/bioinf…