We’ve known about tolerant CD8+ T cells for >25 yrs – but what are these cells?! Prematurely exhausted, stalled effectors, or something else?

Our latest Immunity paper takes a deep dive into this question with some unexpected results, including a link to cancer… (1/)

Plasmacytoid dendritic cells predict survival at the intensive care unit. Learn more in this #JLB article by Steinacher and others.
buff.ly/4dxJ1zg

Check out this #JLB article by Xiao and others where they show that specific inhibition of the IL33 expression or endoplasmic reticulum stress in macrophages can effectively alleviate experimental asthma.
buff.ly/3QCDNIt

Take a look at this discussion on the lineage commitment of early human neutrophil progenitors. #JLB
buff.ly/3yi6ynl

γδ T cells influence macrophages polarization via secreting IFN-γ, IL-17, IL-10, and IL-4, and regulate macrophage apoptosis and pyroptosis with Fas-FasL, perforin/granzyme, and TCR or inflammation promotion. Learn more in this #JLB by Hu's team.
buff.ly/4b7FO7H

GKT137831, a NOX1/4 inhibitor, alleviates high glucose–induced inflammaging in adipose-derived stem cells through the NOX4/ROS/IL-6 pathway & enhances therapeutic effect of adipose-derived stem cells on healing. Read more in by Dong et al. #JLB
buff.ly/4bsMTiS

This #JLB editorial by Li and Zhang highlights the significant role of CD9+ tissue-resident memory (Trm) cells in autoimmune diseases, specifically in Sjogren's syndrome.
buff.ly/44zPKVg

Check out this #JLB Highlighted Article by Chang and others to learn more about Primary Sjogren's syndrome (pSS) buff.ly/4drjGqx

In this #JLB article by Li et al show how adoptive cell immunotherapy innovates breast cancer treatment using patient's immune cells for targeted efficacy.
buff.ly/3JOprAY

Take a look at this comprehensive review by Guan and others of the recent advancements in understanding the inflammatory mechanisms associated with obesity-related glomerulopathy and corresponding treatment approaches. #JLB
buff.ly/3UxCFqE

In this #JLB News and Views article by Freen-van Heeren, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.
buff.ly/4b7n48f

Take a look at this article by Qu and others in the May issue of #JLB ! MZF1 knockdown promotes multinucleated osteoclast formation and differentiation.
buff.ly/3Wx9c2F

Extra! Extra! Read all about the potential for a novel superior cancer immunotherapy targeting the tumor microenvironment in this #JLB article by Tanaka buff.ly/4ac7E1c

Take a look at all that the latest issue of #JLB has in store for you this month! buff.ly/3Wwl59c

End the month learning more about how propionate blunts T helper cell responsiveness in this #JLB article by Han and others buff.ly/4cLoWoI

Exploring risk factors and molecular targets in leukemia patients with COVID-19: a bioinformatics analysis of differential gene expression by Md Asad Ullah and others in the latest issue of #JLB buff.ly/3vFgnea

🚑 Jukema et al. strive to make the emergency department more efficient. Automated neuCD64 and cmCD169 determination can discriminate between bacterial and viral infections at the ED, allowing fast infection diagnostics in the acute clinical setting. #JLB buff.ly/3TDl4Nu

Glucocorticoid-induced TNF receptor family–related protein functions as a costimulatory molecule for murine eosinophils. Learn more in this #JLB article by Narita and others.
buff.ly/4anvLuM

Coudereau's team explains how the activation of NLRP3 and immunosuppression concomitantly occur in the delayed stage of sepsis in this issue of #JLB buff.ly/4ajit2p

Kick off your week with this article by Signoretto et al. This work provides further evidence that human neutrophil-committed progenitors treated with SCF, FLT3L, and G-CSF do not generate monocytes. #JLB buff.ly/3U29PQk