Failed experiment 'habit loops' and how to deal with them: a thread I’ve been reading Jud Brewer MD PhD’s book, Unwinding Anxiety. He explains how our old brain leads us into habit loops that don’t work well in the modern world, and how to update them into more healthy behaviour 1/21

#Optogenetic control p65 which is a transcriptional activator & subunit of #NFκB No previous reports have documented direct optogenetic control of RelA, despite its importance to cellular physiology. biorxiv.org/content/10.110… #PAMPs #DAMPs #Aging

Differential interference with actin-binding protein function by acute Cytochalasin B biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Woohoo! "A guide to single particle tracking" is now online! Together with François Simon & Sven van Teeffelen, we share our thoughts on going beyond MSD analysis in Nature Reviews Methods Primers. doi.org/10.1038/s43586… Free read link: rdcu.be/dTKHd

I think it's good practice for gel electrophoresis methods to be reported in volts per cm of gel length. 100v across a 10cm gel (10v/cm) is very different from 100v across a 20cm gel (5v/cm) And many electrophoresis rig makers like to mess around with gel casting tray sizes.

How do integrins and paxillin interact at #FocalAdhesions? This study presents a 3D structure of the LIM3 domain of #paxillin, revealing a direct association between paxillin and the cytoplasmic tail of the #integrin beta subunit #PLOSBiology plos.io/3TrtFUw

#QuantumDot-Based FRET Nanosensors for Talin-Membrane Assembly and Mechanosensing (Marcelina Cardoso Dos Santos and co-workers) #OpenAccess Cardoso Dos Santos Marcelina Le Clainche Christophe I2BC Paris-Saclay onlinelibrary.wiley.com/doi/10.1002/an…

Oh, wow! A treat from John Baez! arxiv.org/abs/2409.09232 #physics #entropy

R. M. Adar, J.-F. Joanny, Environment-stored memory in active nematics and extra-cellular matrix remodeling. Phys. Rev. Lett. 133, 118402 (2024). dx.doi.org/10.1103/PhysRe…

Working link for the #preprint! (DOI is down for some reason 😑). Stop by the original thread! biorxiv.org/content/10.110…

Congrats on the latest work by the Mao Lab and the Sun Lab team: nature.com/articles/s4428…! What started as theoretical prediction in cell.com/biophysj/fullt…, has yielded many experimental fruits.

Congratulations on our formal PhD Student Yang Yang Yang 's outstanding postdoc work with Bianxiao Cui ! Curvature-sensing of membrane contact sites in iPSC-derived muscle cell - important cell biology for understanding excitation–contraction coupling! nature.com/articles/s4155…

Commitment to cytokinetic furrowing requires the coordinate activity of microtubules and Plk1 biorxiv.org/content/10.110…

Are you ready to apply deep learning-based methods to your data and image analysis problems? If you've already trained a network in your own code, this is for you! #EMBLDeepLearning 🗓️ 17 – 21 February 2025 📍 EMBL Heidelberg 📩 Apply by 25 November ➡️ s.embl.org/mac25-01

A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation dlvr.it/TDPBXv

Want to photo-stabilise microtubules? just write and we can send you CouEpo. doi.org/10.1002/anie.2… Some tool creation papers make new concepts. Others fill in the practical gaps for things that need to exist but don‘t yet. Carina‘s Angewandte Chemie is one of those. Congrats!

Dias Araújo et al IPMC CRBM reveal that perilipins, abundant #LipidDroplet (LD) proteins, differ in their sensitivity to phospholipid density of the LD monolayer, explaining how proteins distinguish btwn different LD populations hubs.la/Q02QsG0q0 #lipids

Fantastic microscopy setup & beautiful movies for membrane receptors in live cells! See Hauke Winkelmann et al. in Nature Communications: doi.org/10.1038/s41467… Flat-field TIRF + super-resolution SIM Single-molecule localization & tracking smFRET Truly inspirational for me! 🔬❤️

Happy #FluorescenceFriday for those who celebrate. There is only one cytoskeleton #trinity

Wanna save $$$ while doing cell transfections. Transfection efficiency extremely low? Use this nature.com/articles/s4428…