Harry Sokol sheds light on the super complex tryptophan pathway in #IBD brilliant presentation 👏👏 #DDW2024

Fantastic study full of information regarding the impact of maternal food additive consumption on gut microbiome and vertical bacteria sharing between #IBD mothers and their infants

Presented by Lin Zhang at Digestive Disease Week #DDW2024

📢 #DDW2024

First in human study of a
bio therapeutic agent MH002 in mild to moderate UC
Severine Vermeire

Promising results

L'équipe Microbiote, Intestin et Inflammation (Harry Sokol Philippe Seksik) et le service de Gastro de l'hôpital St-Antoine entrent en jeu pour faire parler des MICI: youtu.be/D07yJDkPYKs?si…

crsaparis Inserm Île-de-France Faculté de Santé de Sorbonne Université AP-HP afa-Crohn-RCH
#WorldIBDday #lesmicientrentenjeu

Harry Sokol (left), Associate Editor of Gastroenterology, moderates a #DDW2024 session on how the #microbiome determines the impact of nutritional interventions in #GI disorders.

W/ figure from Gil Kaplan MD MPH article: ow.ly/O0LI50RMfHh

#nutrition Harry Sokol American Gastroenterological Association (AGA)

#DDW2024

#Vedolizumab or #ustekinumab after anti-TNF failure in #UC ? A French #RWE comparison. Mathurin Fumery Anthony Buisson

academic.oup.com/ecco-jcc/advan…

Attending Digestive Disease Week? Suzanne Devkota made it easier for you to find everything microbiome! 🙏 Catch my talk on Personalized Nutrition Sunday 8AM (w Kevin Whelan Harry Sokol Jacob Allen) and our session on Microbiome Therapeutics Sunday 10AM (w Tessa Andermann Jessica R Allegretti) 🦠🔬

Long-term outcome of risankizumab in Crohn’s disease: a real-world GETAID study - Clinical Gastroenterology and Hepatology cghjournal.org/article/S1542-…

A Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity and Inflammation - in ⁦Gastroenterology⁩ sciencedirect.com/science/articl…

EFFICACY AND SAFETY OF USTEKINUMAB FOR CHRONIC POUCHITIS: A PROSPECTIVE OPEN-LABEL MULTICENTER STUDY
cghjournal.org/article/S1542-…

Human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice ⁦⁦Gut Journal⁩ gut.bmj.com/content/early/…

Tryptophan is transformed by the host & microbiome into metabolites that shape mucosal homeostasis.

.Harry Sokol, Verdu Lab, Bercik-Collins Lab et al. found tryptophan intervention strategies might help mitigate inflammatory conditions of the small intestine:

journals.physiology.org/doi/abs/10.115…

Long-term outcome of risankizumab in Crohn’s disease: a real-world GETAID study
▶️174 patients exposed >=3 biologics
▶️ steroid-free clinical remission : 47% w26, 46% w52
▶️One year discontinuation : 26% (LOR, 42%; Ir failure, 37%; intolerance, 13%)

cghjournal.org/article/S1542-…

Can probiotics mitigate the clinical effects of antibiotic-associated dysbiosis?

.Harry Sokol & colleagues suggest that the administration of an adequately probiotic within 48 h of starting antibiotics can promote a return to the pre-antibiotic state:

link.springer.com/article/10.100…

Study in Nature Communications by HabermanLab on the Urban-Rural diet-omic roots of IBD in China/Israel (our SOURCE Helmsley Charitable Trust consortium). Shows a gradient of IBD-like microbiome change correlating with time in city spent by villagers.
doi.org/10.1038/s41467…
Sheba Medical Center

Happy to participate in this great day!