Thanks to EFMC & ACS Division of Medicinal Chemistry for the Chemistry Europe lecture by Maria João Matos at #MedChemFrontiers24 !

We invite everyone to follow, read & publish in ChemBioChem & ChemMedChem, YOUR official EFMC journals!

Looking forward to the EFMC-ISMC in Rome in Sept. #medchem #chembio

Last talk of the morning session at #MedChemFrontiers24 is given by Rita Di Martino (Rita Maria Concetta Di Martino) on “Leveraging New Chemical Modalities for Reprogramming IDO1 Half-Life in Cancer Immunotherapy”
EFMC
ACS Division of Medicinal Chemistry

The first talk of the session is given by Jenna Jeffrey (Arcus Biosciences) on the discovery of quemliclustat, a potent and selective small molecule inhibitor of CD73.
#MedChemFrontiers24
EFMC
ACS Division of Medicinal Chemistry

After the coffee break, the #MedChemFrontiers24 programme starts again with the session on “Targeting Immune Checkpoints with Small Molecules”, chaired by Eddy Sotelo (Eddy Sotelo).
EFMC
ACS Division of Medicinal Chemistry
SEQT

Due to an overlapping TC, I couldn’t listen to Tracey Pirali’s talk (and make a post on it), but I knew I could count on Stephan Hacker 😊

Before Stephen Fesik VU Chemical Biology begins his FBDD talk, he shares personal lessons: 1)Follow your dreams. 2)Don't listen to those who say it can't be done. 3)Develop a plan & execute. 4)Try VERY hard. 5)Pay attn to the unexpected.
#MedChemFrontiers24 EFMC ACS Division of Medicinal Chemistry

A packed room at #MedChemFrontiers24 for the talk of Stephen Fesik (VU Chemical Biology Vanderbilt-Ingram Cancer Center Vanderbilt Center for Structural Biology)-- Father of Fragment-Based Drug Discovery. Now discussing FBDD for cancer therapeutics.

lab.vanderbilt.edu/fesik-lab

EFMC ACS Division of Medicinal Chemistry #medchem #chembio #pharma #nmr

Last early-career investigator on the stage for this session at #MedChemFrontiers24 is Olha Kolodiazhna, presenting Enamine Ltd 🇺🇦 latest achievements in the preparation of borylated cyclobutanes via thermal [2+2]-cycloaddition.
EFMC
EFMC Young Scientists Network
ACS Division of Medicinal Chemistry

Next talk of the early-career investigators session is given by Irene Shajan (@WUR) on potent bispecific T cell engagers obtained by tyrosine click chemistry.
EFMC
EFMC Young Scientists Network
ACS Division of Medicinal Chemistry

Next talk of the session at #MedChemFrontiers24 comes from Stanford University, with Franco Faucher (@mbogyo lab) talking about selective substrate identification using chemically modified phage display.
EFMC
EFMC Young Scientists Network
ACS Division of Medicinal Chemistry

The 2nd talk of the ECIs session at #MedChemFrontiers24 is given by Efthymios S. Gavriil (@imperialcollege) on “Discovery of Hedgehog Acyltransferase (HHAT) Inhibitors as a Novel Strategy to Stop Hedgehog Signalling in Cancer”.
EFMC
EFMC Young Scientists Network
ACS Division of Medicinal Chemistry

The early career investigators session starts with a talk by Francesco A. Aprile (@imperialcollege) on targeting challenging proteins using an integrative antibody discovery approach.
#MedChemFrontiers24
EFMC
EFMC Young Scientists Network
ACS Division of Medicinal Chemistry

Another great idea of the #MedChemFrontiers24 programme is a Focus on Early Career Investigators. The session is chaired by Rita Petracca, introducing it with a super-nice metaphor of the “rolling disco”. Well done, Rita!
EFMC
EFMC Young Scientists Network
ACS Division of Medicinal Chemistry
EpigeneticMedChemLab

Last talk of the morning session at #MedChemFrontiers24 is given by Kyle Landskroner (Azafaros) on the development of the L-ido azasugar Nizubaglustat for the treatment of GM1, GM2 gangliosidoses and Niemann-Pick Type C diseases.
EFMC
ACS Division of Medicinal Chemistry

Second talk of the session is given by Lyn Jones (@DFCI_ChemBio), spanning Cereblon molecular glues and next-gen covalent drug discovery.
#MedChemFrontiers24
EFMC
ACS Division of Medicinal Chemistry