Overview by Monika Dolejska of the role of transfer by #plasmids in #HGT

These little extra pieces of DNA are fascinating to study, with their own dynamics, interaction with their hosts & potential for impact in #AMR through the whole #onehealth spectrum

#ESCMIDGlobal2024

I guess not finished yet! 😅 Let’s learn about #horizontalgenetransfer in #resistance to really close up #ESCMIDGlobal2024 🧬💊

Sally Partdrige starts presenting which other elements besides plasmids & transposons can mobilize #AMR genes

Finishing #ESCMIDGlobal2024 at the booth of Gradientech for the last interview for the next #theAMRstudio special episode!

We catch up with Christer Malmberg, Uppsala Antibiotic Center’s first graduate, seeing what he has been up to these last 3 years!

So lovely to meet old friends again 🥰

Can we move from invasive nasal sampling 👃 to analyzing air to track viruses? M. Karatas from KU Leuven works with air viral #metagenomics

This allows to track different virus types moving around, not just human but insect, animals and plants too.

#ESCMIDGlobal2024

Last #ESCMIDGlobal2024 day starting w/ colleague Sofia Jonsson from Uppsala University, exploring the prevalence of #heteroresistance in blood-infecting bacteria

Many had it, even if classified as susceptible. When treatment is taken into account, it increases risk of worse outcome

Christer Malmberg from Gradientech closes the session with their new phenotypic fingerprinting based on #MachineLearning

This allows resistance categorization at even earlier time points & additional information about resistance mechanisms (eg. ESBL carriage)

#ESCMIDGlobal2024

Sometimes #genotype does not match #phenotype & MIC - Sarah L Baines brings the case of fosA, a gene that not always gives fosfomycin resistance to its carrier

Things to consider:
🧬the allele
🦠the bacteria
1️⃣the origin

#ESCMIDGlobal2024

Incredibly cool technology being developed by Accelerate translating holograms (3D images of bacteria under treatment) into #MIC values.

Including information about the #morphology of the bacteria, not just the growth data, make the system faster and better!

#ESCMIDGlobal2024

New frontiers in antimicrobial #susceptibility testing starting with Hugues de Villiers de la Noue, who works with phage susceptibility testing

If we are to use phages as treatment, we need better ways to test if they work: a fast phagogram!

#ESCMIDGlobal2024