.Sam Altman describes the two approaches for AI assistants:

1) the 'self extension'
-- a 'ghost' of the user that acts on their behalf
-- ex: autonomously replies to emails
-- 'it becomes more me, and is me.'

2) the 'senior employee'
-- has the kind of relationship with the user

Three years to get to 500k subscribers. No shortcuts, just consistent effort.

Now the march to 1M and a HUGE blowout in Vegas!

Thanks to all our supporters. ❤️

AI Gene Editing Has Been Open Sourced

david friedberg explains:

'Every single life sciences lab on Earth is using (gene editing) technology today.'

'It has changed everything. It has reset the trajectory of human health, of agriculture, and of industrial biotechnology.'

'We

the besties recently shared their steve jobs stories...

as a tech journalist during the 'peak steve jobs' era, @jason had a bunch of run-ins with the legend

why? because jobs was 'full contact' with the press!

but none were captured quite like this one! 😅

E177: besties in conversation with Sheryl Sandberg

(0:00) welcoming sheryl and remembering dave goldberg

(11:10) what led sheryl to get involved with 'screams before silence'; reaction to sexual violence on and after 10/7

(28:18) paths forward, documentary decisions,

.Chamath Palihapitiya tells the story of his job interview with steve jobs back in 2011

it was the only interview he took after leaving facebook, before he started Social Capital

How Can Scientists Best Become Founders?

david friedberg answers a fan question from james sinka 🍊 bio/acc - Lives in Boston:

'I think the biggest challenge that scientists face when trying to build businesses is shifting from a research and discovery mindset to a product and customer mindset.'

this can be

Silicon Valley's Happy Coincidence: No Noncompetes in California

In the wake of the FTC banning noncompetes nationwide, David Sacks explains how California not allowing these agreements helped accelerate innovation in tech:

'As a result of (no noncompetes in CA), the talent

best fans in the world

Bestie Q&A!: The One Question @Chamath Asks During Every Job Interview

If you want to know whether or not a candidate can contribute to your company, ask them this:

-- take a few minutes to think about something that you are an absolute expert in

-- it does not matter what it