ORBITA-2: Angina Phenotype Strongly Predicts PCI Response dlvr.it/T6w8Qc

Excellent catchphrase to summarise this study! Rasha Al-Lamee & team ongoing research excellence …

As ever, with the statistical methods developed by Frank Harrell, the 22,823 patient-days of symptoms data are utilised, based on work detailed here: youtube.com/watch?v=FI2ncR…. Perhaps one day Bayesian ordinal longitudinal models will be used by all trials...

Rasha Al-Lamee JACC Journals Christopher Rajkumar In a secondary analysis of ORBITA2, Florentina Simader tested how the presence or absence of the classical features of angina, as defined by Rose 1962 definition predicted the placebo-controlled response to PCI.

Rasha Al-Lamee JACC Journals In an innovative n-of-1 study with real and placebo balloon inflations, Christopher Rajkumar asked patients how similar the associated pain was to their everyday symptoms to derive a 'similarity score'. This score strongly predicted their subsequent improvement in angina after PCI.

.Florentina Simader on #ORBITA -2 at #EuroPCR :
📌Poor correlation between symptoms & disease severity
📌Symptom nature is a powerful predictor of the placebo-controlled efficacy of #PCI
📌Rose angina & typical angina are excellent predictors of the placebo-controlled efficacy of PCI

You and Matthew Shun-Shin are our statistical dream team Frank. Thank you

Fantastic to see two new studies from Rasha Al-Lamee's ORBITA programme, presented at #EuroPCR and simultaneously published in JACC Journals. ORBITA2 found PCI was an effective anti-anginal procedure. However, do all patients benefit similarly? How important is the nature of symptoms?

Collaborating with researchers who are bold enough to be truly innovative in clinical research including being all-in on Bayes is an absolute joy. Go ÓRBITA team!! Rasha Al-Lamee Matthew Shun-Shin

#ICYMI Aaysha Cader asked Rasha Al-Lamee & Florentina Simader to summarize the symptom-stratified analysis of ORBITA-2 presented at #EuroPCR !

Christopher Rajkumar Rasha Al-Lamee Michael Foley Florentina Simader Fiyyaz Ahmed-Jushuf Dr Thomas Keeble Dr Peter O'Kane JACC Journals PCRonline 🫀 Sukh Nijjer Prof Darrel Francis ☺ Mk CardioFellows Great Again Matthew Shun-Shin As a statistical modeler who does clinical research, a figure like this is a reason for being - it’s even got Bayesian uncertainty intervals.

As always my team make me very proud. Today we launched our newest ORBITA fellow Florentina Simader who did the most fabulous job of explaining how symptoms predict outcomes from ORBITA-2 JACC Journals Matthew Shun-Shin

Two placebo-controlled studies with a synergistic outcome both published in JACC by two fabulous fellows from the ORBITA team Christopher Rajkumar Florentina Simader

🔥 Important new insights from ORBITA-2 study presented today at #EuroPCR

👉🏼 More angina symptoms do not necessarily reflect more extended coronary disease

👉🏼 The clinical history is a strong predictor of the efficacy of PCI

🚨Interroge your patients!

PCRonline 🫀 Rasha Al-Lamee

JACC Journals Florentina Simader Rasha Al-Lamee The #ORBITA -2 study brings intriguing insights. It seems symptom nature rather than severity drives the efficacy of #PCI in a placebo-controlled context. This suggests that patient-reported outcomes should be a key focus in treatment planning. For detailed analyses and

#EuroPCR #JACC LBCT SimPub: Insights from #REVIVED -BCIS2 trial - Completeness of #revascularization , whether anatomical or viability-guided, does not influence outcomes in patients with ischemic #cardiomyopathy . bit.ly/44JRcV0

Saad Ezad Margaret McEntegart Cardiac Research

#EuroPCR #JACC LBCT SimPub: #ORBITA -2 symptom-stratified analysis - Although symptom severity & nature were poorly associated with disease severity, the nature of symptoms powerfully predicted the placebo-controlled efficacy of #PCI . bit.ly/3QK76cj

Florentina Simader Rasha Al-Lamee

🙏Thanks JACC Journals
for this discussion about

The Influence of
Epicardial Resistance on Microvascular Resistance Reserve

👇
youtu.be/768iGJwNzss

👋 Bernard De Bruyne
Thabo Mahendiran
Rasha Al-Lamee

Imagine us pitching this to the funding bodies. Thank you Medical Research Council

Amazing trial Christopher Rajkumar congratulations. Always love it when balloon up simulates exact angina symptoms.