Wow, wow, wow! Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis nature.com/articles/s4158…

The Feynman point is the name given to the position in the decimal expansion of π where a sequence of six consecutive nines first appears. It is named after the physicist Richard Feynman, who allegedly joked that he would like to memorize the digits of pi up to that point and

Happy to share that this work on the structural biology of #psychedelics is finally out! Big shout out to all involved, especially BryanRoth for all of the support! The structural diversity of psychedelic drug actions revealed | Nature Communications nature.com/articles/s4146…

Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation biorxiv.org/content/10.110… #biorxiv_biophys

Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2 nature.com/articles/s4146…

New preprint from our lab at SLU; dramatic effects of cholesterol on HCN channel in sensory neurons and neuropathic pain: biorxiv.org/content/10.110…

Our new preprint "RhoA activation promotes ordered membrane domain coalescence and suppresses neuronal excitability". doi.org/10.1101/2025.0…

Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.

.Claire Weckerly, Rahn, Gerry Hammond et al. University of Pittsburgh report a novel biosensor, PILS-Nir1, that detects phosphatidic acid in live cells, revealing the lipid’s dynamics with improved sensitivity and selectivity over existing probes. hubs.la/Q03HyBZn0 #lipids #phospholipids

New Article! Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins bit.ly/4neyf58

Now online! Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains dlvr.it/TNGGY5

I am glad to highlight our latest paper in collaboration with Emad Tajkhorshid, PhD on voltage sensing mechanisms of cardiac hERG channels, using a combination of FLIM-tmFRET and MD simulations. More exciting stuff is coming from St Louis and Champaign! nature.com/articles/s4146…

Here is my lunch at Crave cafe. STL sandwich and an apple.

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice nature.com/articles/s4146…

Nice day outside. Lab has a view.

The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell of only ≈ 10 water molecules separating it from the adjacent protein hydration shell.

DREADDs cause baldness (when expressed in particular cells)! cell.com/cell/fulltext/…

In the latest issue! Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains dlvr.it/TPWKmj

Now online! Membrane potential mediates the cellular response to mechanical pressure dlvr.it/TPdCMt