What an emotional day today.. We had to say goodbye to our 2 summer students and let them go back to school/college. This is the thank you note from Jasmin which brought me to tears! 🥲 THANK YOU, Jasmin! 😃

Check out our recent preprint on human mitochondrial Mg2+ channel MRS2! Louis @louistflai used #cryoEM to determine < 3Å structures of this channel & together with functional assays provided insights into the ion translocation pathway and gating mechanism. doi.org/10.1101/2023.0…

Great start into my jet lagged day waking up at 3 am: “We are delighted to accept your manuscript entitled "Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms" for publication in Nature Communications.” 😃

Passionate about electron microscopy? Join us at the Electron Microscopy Resource Center at Rockefeller University …reers-rockefelleruniversity.icims.com/jobs/1257/rese…

The joys of being a PI! Just got the news that my super talented high-school summer student Jasmin Wu got accepted into UPENN! HUGE CONGRATULATIONS! 🥳 I am so proud of you! 🥹😃

Do you want to see me question a 20+ year old structural biology field? Then I invite you to join the #BPS2024 symposium on „New insights into ion channel (and transporter) regulation Tuesday, February 13th at 9.30 am.

Our preprint on magnesium transporter MgtA is out revealing a DIMERIC, not monomeric P-type ATPase if you are gentle! Fun collaboration between 5 amazing labs. biorxiv.org/cgi/content/sh… Rilee @AlexSodt storzlab @NICHD_NIH NIH Max Planck Institute of Biophysics #cryoem

I’m excited to share my first postdoctoral work where we captured the first high resolution structure of the bacterial magnesium transporter MgtA! This project allowed me to learn cryo with Doreen Matthies, molecular simulations with @AlexSodt and function with storzlab.

HUGE CONGRATULATIONS to our PhD student Elissa Moller for winning the BEST student talk @ today’s SMALP WebConference talking about her new mechanosensitive channel MscS cryo-EM structure in native nanodiscs using Glyco-DIBMA! 🙌🎖️🥳🥂 smalp.net

It’s nice to still feel useful for people in my group who thought our filament went after 3 years.. after quickly adjusting the water flow, I was able to find the beam on our T20 😃

We are looking for a talented postdoc to join us by 8/24 to continue our efforts towards understanding the mechanism of Mg2+-transport & oligomerization of P-type ATPases using molecular biology, biochemistry, structural biology (#cryoem) and MD. Please DM me if interested.

Tamir Gonen Tamir Gonen NIH: Just amazing how far #MicroED has come over the years! High resolution structural biology of proteins and drug molecules using electron diffraction of tiny crystals at ultra low electron dose! 🤩

Doreen Matthies to Receive the 2025 Margaret Oakley Dayhoff Award ow.ly/yc2J50TuvTb @NICHD_NIH NIH

After 4.5+ years, our Glacios-Selectris-Falcon4i is finally installed and we are watching Thermo Fisher‘s workflow validation using apoferritin. We are looking forward to finally start using this microscope and producing exciting new structures! 😃

The Doreen Matthies lab is looking for a talented postdoc interested in applying cryo-FIBSEM and cryo-ET/EM to prevent chronic human diseases. If you are a US citizen or permanent resident with a PhD less than 5 years ago, please contact me. tinyurl.com/4a7ehxwm