Commemorate the life and science of our dear departed colleague Jon Widom - this Thurs May 15 1230 pm in Pancoe Auditorium Northwestern MolBioSci Northwestern - our distinguished Widom Lecturer is Prof. Lucy Bai Penn State - Chromatin Accessibility and the 3D Genome

🧵 1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? biorxiv.org/content/10.110… #TranscriptionFactors #IDPs #SingleMolecule #Biophysics

Beautifull work - congrats to all

Excited to share our latest work! Utilizing single-molecule methods, we show how disordered regions guide transcription factor search via sequence-dependent DNA interactions beyond target motifs. A major step toward decoding promoter selectivity. 🧬 biorxiv.org/content/10.110…

Very nice work from my former colleagues at Biology Technion Technion Israel. Congratulations Nir Nir Strugo and Ariel Ariel Kaplan!

Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: biorxiv.org/content/10.110… 1/9

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

More than 1,000 scientists took to the streets yesterday in Buenos Aires and other cities in Argentina wearing gas masks to protest the collapse of science in the country, which they say was initiated by their government. go.nature.com/43SZ4Vi

Our new paper has been published! In this study, we revealed the mechanism by which the efficient transcription by RNA polymerase II is accomplished on nucleosomes containing a histone variant H2A.B. #cryoEM embopress.org/doi/full/10.10…

The secret to how nucleosomes shape the genome | Journal Club | PNAS pnas.org/post/journal-c…

New Online! Nucleosomes as blueprints of genome architecture bit.ly/4mM6wsO

Remote on–off switching of protein activity by intrinsically disordered region: nature.com/articles/s4159…

Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to Thomas Clarke for leading the project! nature.com/articles/s4155…