Compaction/condensation alone is not enough to ensure Polycomb silencing. As usual, any robust effect requires more than one pathway to work synergistically

Braiding topology and the energy landscape of chromosome organization proteins. dlvr.it/RMFfCt

Very interesting results! Could the primordial function of Spo11 topoisomerase be to promote recombination-independent pairing? Makes sense in the light of evolution

A new preprint from our lab that provides more genetic evidence for the existence of quadruplex-based homologous dsDNA-dsDNA pairing

Our hypothesis on the role of C-DNA in homologous DNA pairing is now published in Trends in Genetics authors.elsevier.com/a/1gbhMcQbJ7Wcl If true, it will provide a simple yet robust solution to the mystery of recombination-independent DNA homology recognition.

A new preprint from our lab, where we report the discovery of recombination-independent quelling (RIQ) and suggest that de novo transcriptional and post-transcriptional silencing of repetitive DNA can be induced by the active remodeling of a transiently perturbed chromatin state.

Come to beautiful Colorado! The UCCS Dept. of Chemistry & Biochemistry is seeking applicants for a full-time Instructor position in the area of biochemistry. Min quals: MSc; Preferred: PhD. Apply here: cu.taleo.net/careersection/…

🚨Our new paper describing an unexpected role of #calcineurin signaling in #RNAi-mediated small RNA production is now out in Genetics Society of America - implying a way to quickly adapt to external conditions by altering gene expression levels. #Fungi #Cryptococcus academic.oup.com/genetics/advan…