Exciting application of calcium integrator scFLARE in epilepsy models, with follow up in human patients!

scFLARE leads to a change in clinical practice in humans?  🤯

When we made our calcium integrator scFLARE in 2020 we hoped that it would be used by basic neuroscientists to help dissect neural circuitry but we never imagined that it might lead to a change in clinical practice in…

Deeply saddened by the passing of Lubert Stryer, father of FRET, pioneer of DNA and peptide microarrays, author of the famous Biochemistry textbook used across the world. Many may not know that he was also an extremely generous supporter of the arts and deeply passionate about…

LYTACs pioneered by Carolyn Bertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody…

We are recruiting! Open projects related to enzyme engineering, protein directed evolution, computational protein design, spatial proteomics, RNA tools, protein therapeutics, and molecular technology development for cell biology and neuroscience.

We especially welcome trainees…

“Hybrid incompatibility” occurs when the offspring of two closely related species have health problems or reduced reproductive capabilities, e.g. mules. The genetic basis of hybrid incompatibility has eluded scientists but new work from Molly Schumer shows that a clash between…

Congratulations on this beautiful work! I’m so glad that scFLARE was helpful to you. Shout out to Mateo Sanchez and Wang Lab, the inventors of scFLARE, and Wang Lab and tina kim who developed the predecessors to scFLARE, the FLARE and FLiCRE calcium…

Mark Howarth from the Univ. of Cambridge introduces “click biology”, simple and robust tools for non-linear covalent protein assembly. SpyTag and SpyCatcher were the earliest tools made from S. pyogenes adhesion protein that forms a spontaneous isopeptide bond bw Lys and Asp.…

I loved every minute of my first visit to South Korea, hosted by Hyun-Woo Rhee, the Rhee lab, and the SNU Chemistry Dept. Highlights included a palace tour while dressed in traditional hanboks, silly photobooth pics with the Rhee lab, magic tricks at a hipster cafe in Insadong,…

Huge congratulations to Moungi Bawendi, our former collaborator and winner of the 2023 Nobel prize in Chemistry! Shortly after arriving at MIT I became inspired by the potential of quantum dots (QDs) for biological imaging with single molecule sensitivity and initiated an awesome…

Interested in a faculty position at Stanford? If you are a creative scientist applying structural, computational, and/or biophysical approaches to biological problems, please apply for the Dept. of Structural Biology’s faculty search, deadline Nov 15.

Structural biology is very…

Two mutations convert a natural fatty acyl-CoA synthetase from nonluminescent fruit fly into a luciferase (“FruitFire”) capable of generating light with the synthetic luciferin CycLuc2 in vivo (in the mouse brain). Not a de novo luciferase but shows how new functions can be…

Are you a protein engineer or biochemist looking to do a postdoc in a neuro-focused lab? Join our team! We are hiring 2 postdocs to engineer & apply in vivo activity-dependent enzymes for linking behavioral function with proteomics/RNAseq data. Info here: tinakimlab.org/2023pdpositions