Fascinating article. 86% of SSI pathogens originated with the patient, 59% of isolated species resistant to prophylactic antibiotics

Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery | science.org/doi/10.1126/sc…

Happy to be part of this collaborative project on AI-based drug discovery with Atomwise. More to come on the resulting molecules.....
Department of Anesthesiology & Pain Medicine SickKids Anesthesia and Pain Medicine The Hospital for Sick Children (SickKids)

rdcu.be/dDmEV

Better hope it doesn't have off-target on Nav1.5....

doi.org/10.1038/d41573…

Congrats to my student Tim YT Lee on his new publication on measuring drug effects using iPSC-derived cardiac models. Department of Anesthesiology & Pain Medicine SickKids Anesthesia and Pain Medicine

frontiersin.org/journals/pharm…

Nice collaborative paper with my anesthesiology colleagues SteinbergLab Goldenberg Lab and Greg Hare. Department of Anesthesiology & Pain Medicine

Bilateral Nephrectomy Impairs Cardiovascular Function and Cerebral Perfusion in a Rat Model of Acute Hemodilutional Anemia. journals.physiology.org/doi/abs/10.115…

Makes you wonder what happens on ECMO.

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels | Science science.org/doi/10.1126/sc…

Our latest collaborative paper on the use of inhaled argon to reduce systemic inflammation and improve lung morphology in sepsis. More to come... SickKids Anesthesia and Pain Medicine Department of Anesthesiology & Pain Medicine

doi.org/10.1007/s00383…

Great lineup at Keystone Heart Failure:All Cells Considered meeting in Santa Fe. Thanks for the opportunity to present - no pics since this is a Keystone! Fantastic work presented on cell cross-talk in HF.

#KSHeartFail23

Interesting, not sure how existing fibrosis will be handled. But a step forward.

Stem cell–derived heart cells injected into first patient nature.com/articles/d4159…

The Bruins will always have their regular season......

Go Leafs.

BCH- Anesthesiology, Critical Care & Pain Medicine SickKids Anesthesia and Pain Medicine Department of Anesthesiology & Pain Medicine Boston Children's Toronto Maple Leafs

Congrats to our chair Dr. Bev Orser as she takes over as IARS president, real feather in the cap for her and Department of Anesthesiology & Pain Medicine #IARS23 SickKids Anesthesia and Pain Medicine

Going to be a consistent and expanding problem (was already an issue for small molecule therapies for rare disease):

doi.org/10.1038/s41591…

Congrats to my postdoc W. Dou and grad student Fatemeh on their pub in Nano Letters

Ultrathin and Flexible Bioelectronic Arrays for Functional Measurement of iPSC-Cardiomyocytes under Cardiotropic Drug Administration and Controlled Microenvironments pubs.acs.org/doi/10.1021/ac…

Congrats to my grad student Julia on her new publication in Anesthesiology on a new mechanism for LA cardiotoxicity Department of Anesthesiology & Pain Medicine SickKids Anesthesia and Pain Medicine

Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics pubs.asahq.org/anesthesiology…

Congrats to the team on our new pub showing how young pediatric hearts possess an inflammatory phenotype that may predispose to poor surgical outcomes. SickKids Anesthesia and Pain Medicine Department of Anesthesiology & Pain Medicine

Mesenchymal Stromal Cells Isolated From Patients With Congenital Heart sciencedirect.com/science/articl…

Interesting ariticle illustrating how ketamine has dual actions that limits addiction potential. Might be especially important for use in the pediatric population.

Dual action of ketamine confines addiction liability disq.us/t/49gyrro

Congrats to lab members W. Dou, Manpreet and Julia on their publication in ACS Nano.
Department of Anesthesiology & Pain Medicine SickKids Anesthesia and Pain Medicine

A Carbon-Based Biosensing Platform for Simultaneously Measuring the Contraction and Electrophysiology of iPSC-Cardiomyocyte Monolayers pubs.acs.org/doi/10.1021/ac…

Small molecule activity-modifying chaperone, fantastic. Brilliant biochemistry.

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function science.org/doi/10.1126/sc…

Rescue of large transmembrane protein function by expressing a chaperone. Great way around proteins too big for gene Tx.

Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy science.org/doi/10.1126/sc…

And that Leafs fans is how you win game 7