We posted a preprint, 'Mitochondrial DNA mosaicism in human normal somatic cells' shorturl.at/frLR7. We observed ~3 mtDNA mutations/cell, (2) the rate of new mutation acquisition over a lifetime, and (3) levels of heteroplasmies carried by the fertilized eggs. (Jisong An)
I'm happy to share that our article, published in nature (nature.com/articles/s4158…), highlighting the mutations occurring in our colon due to 'L1 jumping genes'. Genomic mosaicism by L1 jumping begins during early development and continues throughout an individual's lifetime!