In a study funded by #CCBIR , Denis Wirtz Johns Hopkins Medicine et al. developed a #DeepLearning approach to improve 3D tissue mapping bioRxiv biorxiv.org/content/10.110….

What an amazing two days of science! Leaving with new ideas and new collaborations. Thank you UNC Lineberger Yeh Lab Pylayeva-Gupta lab for inviting me!

Submit an abstract by July 1 for the AACR Special Conference on Advances in Pancreatic Cancer Research (September 15-18, Boston), chaired by Peter J. Allen, Stephanie K. Dougan, Tony Hollingsworth, and Alec C. Kimmelman. Learn more:
bit.ly/3ywQG0F
#AACRpan24

So excited I got to give my first talk yesterday, and I am so happy it was at #DDW2024 ! 🤩

What makes an IPMN an IPMN? It's complicated! See our new collaborative work led by Ashley Kiemen that suggests new definitions are needed based on 3D analysis.

The CCBIR-Cancer TEC joint conference at Hopkins was a huge success. Amazing talks, fantastic poster sessions and new connections.

I want to thank Steven Becker of the National Cancer Institute, Sage and Michelle of my office to co-organize this.

NCI PhysicalSciences NCI Cancer Training

Super excited to share our latest review article, just out in @nature, in which we discuss how genetic and non-genetic processes act in concert to drive the metastatic cascade, and new putative avenues to intercept this lethal process.
rdcu.be/dH1JT

In Convergence Science from the May 1 issue—
Transfer Learning Reveals Cancer-Associated #Fibroblasts Are Associated with Epithelial–Mesenchymal Transition & Inflammation in Cancer Cells in #Pancreatic Ductal #Adenocarcinoma , by Guinn et al.
bit.ly/3wNc8xE
Johns Hopkins Kimmel Cancer Center

For the next 3 days, we are hosting the CCBIR/TEC conference at Hopkins. These two center networks are funded by the US National Cancer Institute.

Warm welcome to all participants.

CCBIR = Cancer Cell Biology Imaging Research
TEC = Cancer Tissue Engineering Collaborative

🚨 The CDMRP #PancreaticCancer Research Program (PCARP) FY24 RFA has been released with pre-applications due on June 28 for the IDEA and TRPA mechanisms. Link below:
cdmrp.health.mil/funding/pcarp

PanCAN Let's Win Pancreatic Cancer 💜

Study showing widespread precancer mutations in the pancreas.

It seems normal adults have hundreds of precursors of pancreatic cancer.

It shows how difficult curing aging will be, we can’t just get rid of the billions of oncogenic mutant cells we have.

nature.com/articles/s4158…

It had me at 'the normal intact adult pancreas harbours hundreds of pancreatic intraepithelial neoplasias (PanINs), almost all with oncogenic KRAS hotspot mutations'
Spatial omics of pancreatic cancer
nature.com/articles/s4158…
nature Laura DeLong Wood Denis Wirtz Ashley Kiemen

This is a key question - what constrains our multitudes of PanINs and prevents most of us from developing pancreatic cancer? And could we further harness that mechanism for cancer prevention?

What a great meeting! Amazing speakers and vibrant discussions...I'm leaving with new ideas and collaborations, feeling excited about new directions. Thank you for the invitation and wonderful Glaswegian hospitality Jen Morton 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇺🇦

Nature research paper: 3D genomic mapping reveals multifocality of human pancreatic precancers go.nature.com/3QnldUH

Amazing- human pancreas 80cm3…. That’s a lot of kras mutations - yet lifetime risk of pancreas cancer is 1:60 - cancer is very rare at the cellular level
“mean burden of 13 PanINs per cm3; normal.. adult panc has 100s of PanINs, w oncogenic KRASm.”
nature.com/articles/s4158…

Brilliant 2nd keynote to round off Science and Innovation at Cancer Research UK Scotland #PancreaticCancer symposium - Laura Wood Johns Hopkins Pathology demonstrating the power of machine learning model 'CODA' to enable 3D modelling of PanINs. Incredible spatial resolution (unlike this photo)...

Best part of today was seeing this presented!🌟Glasgow #PancreaticCancer 2024
➡️way too many heterogenous PanINs visualised in 3D! Different KRASm, dominant SBS 1,5 present, why do some progress!❓host factors/TME-great discussions Laura DeLong Wood Fieke Froeling Barbara Grünwald

Lustgarten-funded researchers are stretching the boundaries of science to produce real results for #pancreaticcancer patients! 🙌 2022 grant recipient, Laura Wood, MD, PhD, Johns Hopkins Kimmel Cancer Center, was published in nature. Check it out💜 #ResearchIsFundamental lfdn.org/4bjvwkD

Thrilled to share our latest manuscript at @nature! Our work explores the 3D genomic landscape of pancreatic precancers, revealing their multifocal nature and genetic heterogeneity. Amazing effort by Ashley Kiemen,Laura DeLong Wood and Denis Wirtz!
Paper:nature.com/articles/s4158…