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We have developed the first-in-class photoswitchable agonists for the 5HT2A receptor (serotonin family GPCR). Bifunctional, tethered variants (PORTLs) enable genetically targeted optical control. Belinda Hetzler Dirk H. Trauner NYU Chemistry Weill Cornell Medicine chemrxiv.org/engage/chemrxi…

Débora’s farewell party! (All vaccinated don’t worry). We will miss you 🧚🏻

👇Recent review about the insula! Very impressive🧐

Characterization of distinct populations of positive and negative valence neurons in the basolateral #amygdala (BLA), including inputs, outputs, and roles in punishment avoidance and reward seeking go.nature.com/2Z0nPR0

And, check out the News & Views, A new player in neural circuits of emotions go.nature.com/3BTrMFl

Role of a new molecular-defined population of the BLA in valence (Fezf2+) nature.com/articles/s4159… Congratulations Xian Zhang & Bo Li Lab for this excellent work! Anes Ju & I really enjoyed writing a News & Views on your very interesting findings 📰 rdcu.be/czMRN

Great News and Views Anes Ju!

Molecular Brain(2020) Great paper by Anes Ju Anna Beyeler 🇺🇦 Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex molecularbrain.biomedcentral.com/articles/10.11…

I'm presenting a poster at #SfN2021 tomorrow Nov. 11 at 10:30am CST titled "Human intracranial recordings reveal mixed coding of reward and salience prediction errors in fronto-insular cortices" (P879.04). Happy to chat then, or if it's easier, just ping me directly to discuss 🙃

I am very happy and excited to share our latest preprint from Anna Beyeler 🇺🇦 lab about anxiety and valence signal by an insula-amygdala circuit. Thanks for team effort & congrats to all the authors!👏👏👏

🧐Looking forward to see Anna Beyeler 🇺🇦 's talk today!

Brain surgeries are opening windows for neuroscientists, but ethical questions abound science.org/content/articl…

Links to resources and information about Neuroscience, microscopy, ephys, writing, programming, etc. spikesandbursts.wordpress.com/links/

Interview with BBC News (World) about our research, neurotechnology, its future use in medicine and neurorights bbc.com/reel/video/p0c…

The #sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant #ketamine New from Polymnia Georgiou Panos Zanos @ScireAnimus An Xiaoxian Danielle Gerhard and colleagues nature.com/articles/s4159…

This is what I have been waiting for!

I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines. #b3d

🧠🐭🔭 Neuroscience is in a new era: we’ve never been able to collect as much neural & behavior data as we can now,🔋 by new eng & AI. We aim to build a Brain & Behavior Observatory, building on community #WeNeedYou 📝: pubmed.ncbi.nlm.nih.gov/36240770/ 🧠🐭🔭: BrainBehaviorObservatory.org

🚨✨🧠🐭📰🚨 Interested in how defined neural populations of the insular cortex encode both emotional valence and anxiety-related behaviors ? Check out our work answering this exact question !! nature.com/articles/s4146…