Congratulations to Ben Cravatt of Scripps Research on receiving the 2024 Bristol Myers Squibb Award in Enzyme Chemistry! The Cravatt lab has had substantial impacts ranging from fundamental research to advancing clinical candidates. Hear more during our symposium at #ACSFall2024 !

A big congratulations to Ines Forrest for being named a #CASFutureLeader !!!! #ProudPI ☺️

Together with the Cravatt group, we have a new manuscript out reporting the chemoproteomic discovery of covalent FOXA1 ligands that bind its DNA-binding domain, corrupt its motif preferences, and redistribute it on the genome. 1/11 biorxiv.org/content/10.110…

I am delighted to share that the main body of my postdoctoral work with #BenCravatt in collaboration with Bruno Melillo, #RamnikXavier and Stuart Schreiber is finally out which harnessed photoreactive stereoprobes to expand the ligandable proteome: tinyurl.com/f3uxbjj3.

Integration of DOS with PAL-based chemoproteomics from the Cravatt Lab. Further highlights the power of stereochemically matched probes to ID ligandable proteins. biorxiv.org/content/10.110…

Years ago, the birth of a biotech might be chronicled in a book – such as Vertex in the 'The Billion-Dollar Molecule'. Today, young entrepreneurs can gain insights via Podcasts. This is an illuminating series telling the story of the birth of Belharra Tx. birthofabiotech.podbean.com

Chemoproteomics comes through again...

Chiu, TY., Lazar, D.C., Wang, W.W. et al. Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Nat Chem Biol (2024). doi.org/10.1038/s41589…

#Lupus news: #NIAID -funded researchers found a new class of compounds can reduce #inflammation in cells by targeting a protein linked to lupus. Selective blocking of the protein could lead to new treatments for #autoimmune and autoinflammatory conditions nature.com/articles/s4158…

Excited to have our first paper featured in J. Am. Chem. Soc.! Kudos to the brilliant minds of Amy (Katie) Bracken, Colby Gekko, and our stellar team! Immense appreciation for the insightful feedback from reviewers and editors. pubs.acs.org/doi/10.1021/ja…

In a new Nature Chemical Biology study, Chris Parker and Teijaro Lab have developed an inhibitor for SLC15A4, a protein that was largely considered 'undruggable', offering hope against autoimmune diseases such as lupus and Crohn’s.

Read the full press release below: ow.ly/jBmA50QqbQt

nature.com/articles/s4158…
Pleased to see this one in print. What a journey with the parker lab Chris Parker! Great example of merging chemical biology and immunology to generate an exciting tool to probe the immune response. Congrats to everyone involved and all the hard work!!

Excited for Belharra and its recognition - congratulations to the whole team!!

Less than one month until the deadline for Scripps Research Graduate Program PhD apps. We encourage ALL interested students to apply. As always our application is FREE. We don’t want your money, we just want the best people. #phd #STEM #science #gradschool tinyurl.com/yc32pk7b

Spread the word! Come be our colleague!

Scripps Chemistry is searching for a Tenure-Track Assistant Professor with a focus on organic chemistry and synthesis, broadly defined.