Inheritable 'memory' genes drive #cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset! With #ArchishmanRaju led by Suvranil tinyurl.com/4pef8scy

🎉 Excited to share the latest work from our lab uncovering an unappreciated role for the SWI/SNF PBAF complex at repressive chromatin🧬 Led by Elena Grossi and now published Molecular Cell cell.com/molecular-cell…

Χριστὸς ἀνέστη!

Great paper, congrats to the authors! nature.com/articles/s4158…

Uplaćeno: 120.760.741 din. Isplaćeno: 120.160.653 din. Ukupan broj isplata: 7.228 Do sada smo sakupili više od milion € za nadoknadu plata nastavnicima, ali imamo još oko 2000 nastavnika na listi čekanja. Potrebno nam je još donacija. fondacijaalekkavcic.org/doniraj/

Srećan prvi milion, pumpaj!

Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!

This is super similar to what we recently observed for Npm1c… somehow slow-proliferating HSCs were protected? Is this a mechanism to prevent transformation in highly potent, usually quiescent HSCs? nature.com/articles/s4158…

There is much enthusiasm about the scaling of LLMs capabilities, especially among non-experts. Who are the AI technical experts expressing confidence in the scaling of LLMs capabilities? Who among them do not have significant financial conflict of interests ?

Enhancers, how do they work (in vivo)? To find out, we mutagenized 7 human enhancers comprehensively in 12bp blocks and scored for activity in developing mouse embryos. rdcu.be/erD22 nature #mutagenesis #noncoding #enhancers

A Toronto man ran 1,105 kilometers (687 miles) over a year, carefully planning his routes to form the shape of a dancing figure

1. If you want hope in this dark moment, listen to chant of "no more war" that broke out among the thousands that came out to hear Bernie Sanders in Tulsa, Oklahoma. There is only one off-ramp from Trump's mad rush to war: the quick mobilization of an anti-war opposition. The

Our paper on detecting and quantifying clonal selection from a single bulk sequencing sample is out! This was a great collaboration with paresh vyas, Thomas Höfer, Asger Jakobsen and Naser Ansari-Pour. Read the full story here: nature.com/articles/s4158…

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In Cell, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. sciencedirect.com/science/articl….

Odlična, hvala za epizodu, hteo sam da pohvalim ovu epizodu a ne "puteve" koje nisam slušao.

Rapid epigenomic classification of acute leukemia | Nature Genetics nature.com/articles/s4158…

A cancer therapy targeting the interaction between metabolism & protein synthesis. Dietary restriction of arginine and proline depletes polyamines, which in turn causes ribosome stalling at codons with A in the third position. This shifts the balances towards cell ...

I did a summer internship at the Gurdon Institute in 2013 I remember the moment when Sir John Gurdon entered the library after printing out papers he wanted to read. I remember him always taking the stairs and never using the elevator, at the age of 79 or 80, a true inspiration.

Detail, The Bewitched Man also known as The Devil’s Lamp. Artist: Francisco de Goya. Date: 1798. Medium: oil on canvas. Dimensions: 42.5 x 30.8 cm. Collection: The National Gallery, London.