Somatic mutation rates scale with lifespan across mammals | Nature nature.com/articles/s4158…

Gavin was a brilliant PhD supervisor, highly recommend.

I don’t get it.Brazil is experiencing the largest dengue epidemic of its history. Zika co-circulates;we were epicenter few years ago. And ⁦Wellcome⁩ does not include South America as eligibility requirement for this grant,only Asia and Africa😐 wellcome.org/grant-funding/…

If you haven't seen Keira yet at #Microbio24 and if plasmids? Is the question that brought you here, then make sure you stop by.

Interesing! 'On the Evolution of Chromosomal Regions with High Gene Strand Bias in Bacteria'. In some bacteria a chromosomal region with high gene strand bias harbors rRNA, tRNA and conserved genes. Let's se how this story continues! Congrats to authors
biorxiv.org/content/10.110…

What happens when you search hundreds of thousands of sequence datasets for distant homologs of your favorite animal virus genes?

Mostly, you find new and wild viruses.

But you also learn about evolution, horizontal gene transfer and gene modularity

👇
biorxiv.org/content/10.110…

Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here

nature.com/articles/s4158…

Or just stick around 🧵

We show that changing the rate-limiting step can give rise to epistasis.
The original enzyme is limited by binding - mutations accelerating the chemical step have no effect.🛑
Once a mutation that improves binding is introduced, these other mutations can boost activity.⏩
3/🧵

With co-organisers Rebecca Glover Danna Gifford and James Price (Brighton) we're looking forward to a day of talking mathematical modelling and data analysis with a view to support the future of AMR policy.

We're looking for a varied programme of speakers so please do volunteer!

Great opportunity!

Meet those celebrating the mathematics of Timothy Gowers this week 📸🧮✅ newton.ac.uk/event/ooew04/

Very sorry to hear Peter Higgs has died. I was fortunate enough to meet him several times, and beyond being a famous physicist - I think to his embarrassment at times - he was always charming and modest. And of course his name will be remembered as long as we do physics in the…

Hot off the press!🔥We tackled the challenge of defining causal variants and genes in complex diseases by #GWAS and single-cell multiomics.

Delighted that our statistical method SCENT is now published in Nature Genetics with Soumya Raychaudhuri সৌম্য রায়চৌধুরী✨⭐️
nature.com/articles/s4158…

Tweetorial👇

Back in November, Google announced 2.2 milllion new materials.

Today, a paper in Chemistry of Materials from Ram Seshadri and Tony Cheetham dismantles that claim

pubs.acs.org/doi/10.1021/ac…

Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in Genomics England ???

I didn’t initially either, but here is the story of RNU4-2 🧵1/9

So lovely to have a natter with Jonathan Milner for the very first episode of the Milner Centre for Evolution podcast series. One of the loveliest chaps you could ever meet and passionate about evolutionary research and education.
Listen here: podbean.com/eas/pb-uewmu-1…
More podcasts on the way!…

A mechanistic step in the genesis of secondary chromosomes from plasmids... >250 kb you can't succeed without XerCD, cannonic sites and FtsK ! 👏Florian Fournès CORNET François Eduardo Rocha ...biorxiv.org/content/10.110…

Ovarian cancer research desperately needs more money. It is very poorly understood. Some subtypes, such as mucinous (which happens to be the type I had), are resistant to standard OC chemotherapy regimes and yet there are no trials - or plans - to address this. 6/8

Congratulations to Jasper on his new work in bioRxiv describing a new Type IV restriction system in V. cholerae which is embedded in the middle of a Type I restriction operon. This system targets glucosylated 5 hydrox methyl cytosines 1/

biorxiv.org/content/10.110…