House Oversight votes 40-1 to advance the Biosecure Act to effectively force dozens of biopharma companies to cut ties with WuXi AppTec and four other Chinese biotech suppliers by 2032 - endpts.com/house-committe…

$DVAX CRL cited the destruction of “data source documents by a third-party clinical trial site operator for approximately half of the subjects enrolled in the trial.” endpts.com/destruction-of…

NEW: I sat down (virtually) with biotech's Renaissance man, Siddhartha Mukherjee

We talked about AI, his slew of ambitious biotech startups, and how he got into writing epic, Pulitzer-winning tomes on medicine and science

The latest Endpoints News Slack edition:
endpts.com/the-endpoints-…

When a topic has been evergreen for at least my entire career the need for more sticks starts to make a lot of sense. (no paywall)
pink.citeline.com/PS154696/Do-It…

Hey, if you're planning to be in San Diego June 3, we've got a biotech event planned you should check out. I'll be chatting with Aviv Regev, Matt Gline and others.
endpts.com/trailblazers-i…

⚡️This Thurs: The FT/Endpoints US Pharma + Healthcare summit. Chats with:
* U.S. FDA's Tala Fakhouri on AI
* FTC's Rahul Rao on antitrust
* Biogen CEO Chris Viehbacher on everything
+ Ro CEO Z Reitano, Eikon Therapeutics CEO Roger Perlmutter, Lux Cap's Josh Wolfe
uspharma.live.ft.com/agenda

Countries struggle to draft ‘pandemic treaty’ to avoid mistakes made during COVID apnews.com/article/pandem…

Across two clinical trials, gene therapy restores hearing in children deaf since birth:

+ 10/11 children can now hear after receiving a gene therapy from Shanghai Refreshgene Tx

+ 2/2 children from a Regeneron study

endpts.com/across-two-cli…

Few recall that first clinical use of CRISPR was in China (for CAR-T cancer treatment)--even though Carl June called it a 'Sputnik' moment.

But that all came to an end with the CRISPR babies scandal.

Now from from the scorched ashes, gene editing rises again in China.

Senate appropriators question FDA commissioner on H5N1 virus prep -
endpts.com/senate-appropr…

New: AstraZeneca is withdrawing marketing authorization applications for its Covid-19 vaccine globally, company spokesperson confirms to Endpoints News

Statement below

WuXi Apptec and BGI are calling out House Oversight chair Rep. James Comer for lying in his most recent letter to Dr. Robert M. Califf on FDA's missteps in China - endpts.com/house-oversigh…

CMS is out with new guidance to limit industry meetings for next round (2027) of Medicare drug price negotiations - PhRMA and I Am Biotech are not happy endpts.com/industry-group…

New bipartisan draft bill out this morning from Ron Wyden et al. would pay hospitals more to combat drug shortages - endpts.com/bipartisan-dra…

$AMGN says it kicked off trials for Keytruda and Opdivo biosimilars (that's at least 4 biosimilars for Keytruda in dev. so far...)

But just $30M in Q1 Humira biosimilar US sales (vs. $1.8B for $ABBV)
investors.amgen.com/news-releases/…

Supply, supply, supply... and price! For once, competition in pharma drives price (moderately) down.
$NOVOB miss on Wegovy sales with 9.4 billion DKK vs 10.4 BBG consensus last week.

$NOVOB -3% on Copenhagen
x.com/bio_clouseau/s…

Boehringer puts a target on Humira, says pushing it off formularies is necessary - endpts.com/boehringer-put…

The first $UNH hearing is getting underway.

Senate Finance Cmte chair Ron Wyden bashes 'failures of CEOs like Mr. Witty … who can't figure out how many people have had their data stolen.'

More on the pressures on UnitedHealth that brought us to today →

x.com/ddiamond/statu…