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I have a PhD in walking on eggshells

Erik she is fuzzy,
she is armored,
i will not allow her to be dishonored
(tell me where you live)

she is beauty,
she is grace,
she is leathery on the face,

Michael Addyman Jerry Coyne I assume you understand the physics of:
Anchored tissue that has ciliated cells that force the movement of stuff over their surface
Unanchored tissue where the same biology as above makes that tissue move.

Michael Addyman Jerry Coyne The cells that make xenobots are already going to be epithelia (inc. cilia that make them move around).

The cells they are collecting with the broom-like cilia movement are cells that are already going to be epithelia (inc. cilia that make them move around).

Michael Addyman Jerry Coyne There’s a disconnect between what I’m saying and what you are understanding. I always take that onto myself.

Because they coalesce - not weird, well-established biology - into the epithelial layer they were going to form had they not been taken out of the embryonic

Colin Wright Same here for same charge.

Right wingers deffo love funding loud, pro-choice, non-homophobic, sciencey women 🤣

When I was about to give birth, the nurses were prepping things and a random male staff member that I hadn’t seen yet popped in and just stood across from me at the end of the bed. My nurse was great and she said “what are you doing?” and he said “I’m here to observe.” She asked

Michael Addyman Jerry Coyne Making balls out of this epithelial surface, including of course the beating ciliated cells that act like paddles, that then move around the dish is, honestly, the least original observation ever.

That those beating paddles sweep like brooms other cells you stick near them is

Michael Addyman Jerry Coyne Now the cells themselves are those that make a mucociliary barrier. There are some cells that secrete mucus, some that move salt, and some that make cilia - the little beating hairs that make surface flow happen.

Michael Addyman Jerry Coyne In a lab, the piles are made by pooling them into dips, using a fine pipette (even one controlled by your tongue), spinning them gently, etc.

This is not xenobot IVF. It’s simply the chemistry of these cells. They split, they stick.

Michael Addyman Jerry Coyne We’ve used this property for *decades* to study how cells work when they are connected or disconnected from other cells.

We know how this property is mediated.

And it’s no surprise that *anything* that collects piles of these cells in an appropriate environment drives those

Late supper for a school night

Michael Addyman Jerry Coyne OK, let’s try this.

The cells in this tissue require a certain level of calcium ions to stay together. If you remove calcium from their environment, they split from each other. If you put them back in close proximity and add the calcium back, they stick back together.

It turns out that the FHI doesn't have an F.
theguardian.com/technology/202…

Iain Brassington 🇪🇺 Road trip.

Michael Addyman Jerry Coyne 1. Balls of epidermal cells, where a sub-population of those cells are ciliated. Ciliated cells move stuff around. Including unanchored balls of the epidermal tissue they are part of.

2. Because it’s not an initial cell that miraculously spawns these things. It’s a dissected