#TeamRocket is honored to sponsor this year’s #BridgingLivesPKD Conference in partnership with the Pyruvate Kinase Deficiency Foundation and Thrive w/ Pyruvate Kinase Deficiency Organization. Learn more: bit.ly/3WjscBe.

Recently, #TeamRocket had the honor of engaging with the #PKDeficiency community at #BridgingLivesPKD hosted by Thrive w/ Pyruvate Kinase Deficiency Organization & Pyruvate Kinase Deficiency Foundation. Thanks to everyone who brought this successful event to fruition for the patient and advocacy communities. #PKDConference #PKD

Last week, we enjoyed presenting at Thrive w/ Pyruvate Kinase Deficiency Organization's 2nd International Pyruvate Kinase Deficiency Conference. Our team members discussed how the Peak Registry is seeking to make #pkdeficiency (PKD) data more accessible and shared insights from our Phase 3 ACTIVATE-KidsT study.

When all that hard work and planning pays off, sponsors and donors come together, and people and families with #PKdeficiency are served, we call that #success! 🥳 Thank you to everyone! Looking forward to #PKDconference2026! #pyruvatekinasedeficiency #rareanemias

#Intheroomwhereithappened, Dr. Grace, Tamara Schryver, & Alejandra Watson discuss the patient & caregiver perspective of how the #pkdguidelines came together. Sponsored by Agios, catch this episode of the podcast ow.ly/58OJ50SNGIS #pkdeficiency #pyruvatekinasedeficiency

Tamara Schryver, President of Thrive w/ Pyruvate Kinase Deficiency Organization discusses her journey with pyruvate kinase deficiency and the importance of guidelines. Available now: JustListenPod.com Sponsored by Agios

Thrilled to share results of Agios' ACTIVATE-Kid transfusion-dependent trial: 28% of patients in the mitapivat arm achieved a transfusion reduction compared to 12% in placebo arm; not statistically significant but clinically meaningful. #pkdeficiency investor.agios.com/node/17541/pdf

What do the #redbloodcells look like in an adult with #pkdeficiency who has had her spleen removed? A case-study highlights #RBCs as they undergo #hemolysis and adapt. 🩸 ow.ly/WUkI50SREPR #pyruvatekinasedeficiency #echinocytes #hematology #rareanemias #PKD #echinocyte

1/ Do you know what pyruvate kinase deficiency is? A short 🧵

2/ Pyruvate kinase (PK) is a critical enzyme in the glycolytic pathway. It is primarily responsible for converting phosphoenolpyruvate to pyruvate while generating ATP.

3/ PK deficiency, an autosomal recessive genetic disorder, results from mutations in the PKLR gene. This mutation impacts the red cells' energy metabolism, causing ATP shortage, dehydration, and abnormal membrane functions.

4/ The deficiency leads to chronic haemolysis and ineffective erythropoiesis, with symptoms ranging from mild jaundice to severe anaemia and even organ failure.

5/ Iron overload, both due to transfusions and increased iron absorption, can cause significant morbidity, including cardiac failure, liver disease, and endocrine dysfunction.

6/ Enhanced levels of 2,3-BPG in patients shift the haemoglobin-oxygen dissociation curve to the right, improving oxygenation in tissues and sometimes aiding anaemia tolerance.

7/ Biochemical testing results for PK levels should be interpreted with caution due to potential false normal readings caused by factors such as increased reticulocytes, recent transfusions, and incomplete removal of platelets and white cells.

8/ These complications, alongside the expression of compensatory isoenzymes and kinetically abnormal PK enzymes, can mislead diagnostics. International guidelines* advise against using PK enzyme activity to predict disease severity or progression. *thelancet.com/journals/lanha…

9/ Do you know the morphological features of PKD? Image source: ASH image bank

10/ Learn this and more with our morphology course Full-colour textbook | Over 6 hours of video lectures | Assesments and CPD certificates | Free global shipping | 25% off Enrol today 👉 bit.ly/3PR4md5

Not sure how to get involved in the PEAK Registry? Here's the cheat sheet link for sign-up and a cheat sheet! peakregistry.com/?publicpage=pa… #pyrvuatekinasedeficiency #pkdeficiency #PKD #rareanemia #peakregistry

The CDC is issuing an alert about increases in human #parvovirusB19 which can lead to serious health risks in people with chronic #hemolyticanemias like #pyruvatekinasedisease. Consider wearing a mask for prevention.😷 emergency.cdc.gov/han/2024/han00… #pkd #rareanemias #pkdeficiency