Science Immunology
@SciImmunology
Official twitter account for the journal Science Immunology. Also find us on Facebook: https://t.co/KRKjcvpZG1…
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https://www.science.org/journal/sciimmunol 20-10-2015 14:20:02
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A “study, done in mice, suggests that the beneficial effects of exercise may be driven, at least partly, by the immune system.' Read more in News Medical: brnw.ch/21wFfBq
New research involving patient samples underscores how #SARSCoV2 vaccines can reinvigorate spike-specific T cell responses. Marcus Buggert Karolinska Institutet
Read more: scim.ag/59K
Check out our new study in Science Immunology. Despite signs like increased PD-1 expression on spike-specific CD8+ T cells, hinting at T cell exhaustion, our findings reveal enhanced functionality of T cell immunity after mRNA booster vaccination.
science.org/doi/10.1126/sc…
In 2021, scientists from University of Pittsburgh showed that provoking mild gut inflammation in mice trains their innate immune response to gut infection through IL-17 signaling in #lymph node fibroblastic reticular cells.
Learn more: scim.ag/58i #WeekendReads
Masked #cytokine designed by University of Chinese Academy of Sciences UT Southwestern Medical Center scientists can jumpstart #antitumor immune response and slow tumor growth in mice without severe toxicity.
Learn more from the 2022 study: scim.ag/584 #WeekendReads
Vaccination after a #SARSCoV2 infection does not lead to CD4+ or CD8+ T cell dysfunction, suggests a new study from Marcus Buggert involving patient samples. Karolinska Institutet
Learn more: scim.ag/57t
A recent study found germinal center-like structures in fish spleens. Now, a Focus describes the “consequences for our understanding of the immune system of the ancestor common to all vertebrates.”
Focus: scim.ag/575
Study by Oriol Sunyer: scim.ag/576
A new study defines the structure of peptide-centric #CAR 10LH in complex with the #neuroblastoma peptide PHOX2B and #HLA with implications for the design of future anti- #cancer #CAR TCell strategies. SgourakisLab
📄: scim.ag/56k
Circadian rhythms play a role in human vaccination responses, where patients vaccinated in the morning experience a better response to vaccines compared with patients vaccinated in the afternoon/evening, according to a 2022 Science Immunology Focus.
📄: scim.ag/56a
New work in mice suggests that disrupting—rather than amplifying—one cytosolic RNA sensing pathway in dendritic cells can make tumors more susceptible to both #immunotherapy and radiation.
Read more: scim.ag/55c
A new Focus describes the implications of a recent study that found germinal center-like structures in the spleen of rainbow trout.
📄: scim.ag/54f Oriol Sunyer Penn
Focus: scim.ag/54e MPI of Immunobiology & Epigenetics
New structural biology research from SgourakisLab describes how a peptide-centric #ChimericAntigenReceptor called 10LH recognizes peptide PHOX2B, presented by #HLA and commonly upregulated in #neuroblastoma .
Learn more: scim.ag/53F
The December issue of Science Immunology is out! This week features #GerminalCenter -like structures in #fish , how #MAVS signaling puts the breaks on #DC anti- #tumor immunity, & structural principles of #CAR antigen recognition! New content added every week!
science.org/toc/sciimmunol…
Now in Science Immunology: SgourakisLab reports #CrystalStructure of peptide-centric #ChimericAntigenReceptor ( #PCCAR ) complexed w/ #HLA & #neuroblastoma peptide #PHOX2B , offering blueprint for engineering CARs that optimally recognize #tumor -assoc antigens!
bit.ly/SI-adj5792
By identifying the “origins” of stem-like cancer-killing T cells, a 2021 Yale School of Medicine study may help inform efforts to convert cold tumors into hot tumors that are more responsive to checkpoint blockade immunotherapy. scim.ag/52q #WeekendReads