It's welcome news that the drug, Kymriah has been approved for routine use on the NHS in England and Wales!

It is an option for those 25 years and under with the B-cell acute lymphoblastic leukaemia, which has relapsed or is refractory.

More 👇
bit.ly/3Ucch6P

3) In this first study researchers showed that the virus can persist in the body more than a year after Infection.
thelancet.com/journals/lanin…

CAR-T recipients have significantly higher seroconversion rates with 4+ COVID19 vaccine doses compared to 2 doses. #CART recipients with other B cell #hematologic malignancies had a significantly low rate compared to those with RRMM. astctjournal.org/article/S2666-…

New phase 1/2 trial of personalised cancer vaccines for advanced liver cancer

The vaccine has up to 40 neoantigens, identified by tumour sequencing, and is co-administered with IL12 and a PD-1 inhibitor, to unleash the T cell response

Of 34 patients, 3 had a complete response,…

Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial - thelancet.com/journals/lanha… #leusm #AML

The FDA just approved cilta-cel for early relapse in myeloma (1 prior line of therapy, including PI and IMiD, and refractory to lenalidomide).

My thoughts on the approval of cilta-cel for early relapse in myeloma.

An educational thread:

#mmsm

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Every now and then a discovery is made that reveals a completely new concept - here's one of them

As we age, we lose immune function. One reason is that cells of the innate immune system are produced at the expense of adaptive immune system cells (B and T cells)

This happens…

You could be someone’s one in a million. You in?
→ bit.ly/3TvDnW1

We’re a squad that saves lives. We’re 1 Million United.

At the The BMA Patient Info Awards last week, we were thrilled to see our sickle cell project named one of the 10 best patient information resources the UK!

Take a look at the resources here: bit.ly/43fcYiB

GSK announces positive results from DREAMM-8 phase III trial for Blenrep versus standard of care combination in relapsed/refractory multiple myeloma | GSK gsk.com/en-gb/media/pr…

New Research: Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases: Introduction

In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total… frontiersin.org/articles/10.33… #immunology

“Supportive Care of Hematopoietic Stem Cell Donors”
Another superb manuscript just published in Clin Hematol Int. the official journal of IACH
EBMT Nurses SFGM-TC BMT InfoNet Indus BMT Group SSBMT الخلاياالجذعية chi.scholasticahq.com/article/92460-…

CONGRESS | #Tandem24 | Alexandra Gomez-Arteaga Weill Cornell Medicine discusses the efficacy of PTCy and Orca-T as forms of GvHD prophylaxis. Orca-T showed superior overall survival versus PTCy (94% versus 77%) #AMLsm #leusm #MedicalCongress #MedicalEducation

New #JITC article: Cardiovascular toxicities associated with bispecific T-cell engager therapy bit.ly/3wmRxQl Stephanie Feldman Narendranath Epperla Daniel Addison, MD

#EPICOVIDEHA findings underscore the critical need for tailored approaches to manage COVID-19 in patients with haematological malignancies, emphasizing the importance of vaccination, early intervention, and ongoing research efforts. 🩺💉

link.springer.com/article/10.100…

Did you spot the incredible moment Nick met Marius, his stem cell donor and lifesaver, on BBC Breakfast this morning?
Nick was diagnosed with myelodysplastic syndromes (MDS) in 2021, a form of blood cancer where your body produces faulty red blood cells.

Prevalence of Immunosuppression Among US Adults jamanetwork.com/journals/jama/…

Donor disclosure & genetic testing should be discussed with donors during predonation consent & transplant centers should report potential donor genetic findings to registries. Read more recommendations from the World Marrow Donor Association: ow.ly/R5NG50QArI1 WMDA

Chronic #GVHD appears closely associated with subsequent neoplasms and nonmalignant late effects in long-term adult survivors of #HCT for hematologic malignancy. Increasing severity of cGVHD was associated with the highest magnitude of risk. Read more: ow.ly/JyvE50Qy7P3

SARS-CoV-2 genome sequence prevalence and growth rate update: 31 January 2024 - GOV.UK gov.uk/government/pub…