🩸 Direct Oral Anticoagulants (DOACs).

🟡 dabigatran

🟡 rivaroxaban

🟡 apixaban

🟡 edoxaban

🟡 betrixaban

☑️Warfarin and DOAC Comparisons.

1⃣ Compared to warfarin, DOACs have rapid onset action and relatively short half-lives; hence, they carry out their function more…

Which antibacterial drug works by disrupting the DNA of microbial cells?

⚠️Thiazide Diuretics and NSAIDs.

The effectiveness of thiazide diuretics may be reduced by NSAIDs (except low dose aspirin).

💊Alendronic Acid Dosage l Treating Osteoporosis.

☑️Usual Adult Dose.

10 mg orally once a day or 70 mg orally once a week.

☑️For the Treatment of Glucocorticoid-Induced Osteoporosis.

5 mg orally once a day

☑️For the Treatment of Glucocorticoid-Induced Osteoporosis in…

💊Patients should be started on a standard-release preparation of metformin and advised to swallow tablets whole with a glass of water with or after food to minimize GI upset.

🔴Phenytoin can cause hematological disorders and osteomalacia by inducing folic acid and vitamin D metabolism.

🎇 NEW FDA MEDICINE APPROVAL.

⚕️ Medicine: Xolremdi ®

💊 Active ingredient: mavorixafor

✔️ Indication:

To treat WHIM syndrome (warts, hypogammaglobulinemia, immunodeficiency and myelokathexis).

WHIM syndrome is a very rare congenital immunodeficiency disorder characterized…

💩Senna and Melanosis Coli.

Chronic use of senna can cause melanosis coli, a benign condition that causes black or brown discoloration of the colon wall.

People with melanosis coli may never know they have the condition because it does not cause any symptoms.

💟Antidysrhythmic Drugs (unclassified in Vaughan-Williams System)

🔸digoxin - rapid atrial fibrillation

🔹adenosine - SVT

🔸atropine - sinus bradycardia

🔹isoprenaline - heart block

🔸calcium chloride - ventricular tachycardia due to hyperkalemia

🔹magnesium - ventricular…

Vancomycin May Be Losing Strength Against Common Deadly Infection drugs.com/news/vancomyci…

💊6 Clinical Uses of ACE Inhibitors

1⃣ hypertension

2⃣ heart failure

3⃣ diabetic nephropathy

4⃣ in patients at risk of ischemic heart disease

5⃣ following myocardial infarction; especially with ventricular dysfunction

6⃣ chronic renal insufficiency, to prevent progression

⚫️Iron

☑️ Iron is normally absorbed in the duodenum and proximal jejunum.

☑️ Typically 5-10% of dietary iron is absorbed (about 0.5-1mg per day), but this can be increased if iron stores are low.

☑️ Iron must be in ferrous form for absorption, which occurs by active transport.…

🎇 NEW FDA MEDICINE APPROVAL.

⚕️ Medicine: Anktiva ®

💊 Active ingredient:

Nogapendekin alfa inbakicept-pmln

✔️ Indication:

To treat bladder cancer.

⚙️ Mechanism of action:

IL-15 receptor agonist.

More details 👇

accessdata.fda.gov/drugsatfda_doc…

🔴Baclofen, a drug used to treat muscle spasticity and intractable hiccups, works by activating the GABA B receptor. Baclofen is itself a derivative of the inhibitory neurotransmitter, GABA.

⚠️ACE Inhibitors Contraindication.

ACE inhibitors are contraindicated in patients with renal artery stenosis due to the risk of azotemia.

What is Azotemia?

Azotemia is a biochemical abnormality defined as elevation or buildup of nitrogenous products (BUN-usually ranging 7 to…

🫁 Montelukast Facts.

✔️indications include maintenance treatment for asthma; exercise-induced bronchospasm; and allergic rhinitis.

✔️leukotriene receptor antagonist (D4); resulting in decreased inflammation and relaxation of smooth muscle.

✔️associated with neuropsychiatric…

🔵Aspirin irreversibly inhibits COX to reduce production of pro-aggregatory factor thromboxane from arachidonic acid, reducing platelet aggregation and the risk of arterial occlusion.