Clinical practice guidelines do not address many scenarios in patients w/systemic lupus erythematosus (SLE). In some countries patients lack access to biologics. Read this Educational Review of options for initial treatment of nephritis in patients w/SLE.
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Acquired cystic kidney disease (ACKD) can occur in patients w/CKD & kidney failure, & its incidence increases w/dialysis duration. Read these Clinical Insights on prevalence of ACKD in children.
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Most studies of patient outcomes re Shiga toxin-producing Escherichia coli-hemolytic uremic syndrome (STEC-HUS) focus on kidney status at last assessment. Read this Original Article on kidney function changes during follow-up & long-term kidney outcomes.
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In pediatric kidney failure, native kidneys may pose a risk to successful transplant outcomes. Read this Review of indications for native nephrectomy & current knowledge gaps; plus, a surgical perspective re timing & approach. Free access this month.
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IgA nephropathy is a genetically complex multifactorial trait. Over the past decade, population-based genome-wide association studies have identified >30 IgAN risk loci. Read this Review of the state of genetic research in IgAN.
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Medication nonadherence is a barrier to HT control. The CDC recommends 90-day fills yet antihypertensives are often dispensed as 30-day fills. Read this Original Article on fill duration in pediatric HT, adherence, & disparities.
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HUS may cause AKI in children. Patients may present w/kidney abnormalities years after HUS recovery. Read this Original Article on the long-term outcome of Shiga toxin-producing Escherichia coli-associated HUS in pediatric patients. #OpenAccess
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Nuclear factor kappa B family plays a central role in the human immune system. Heterozygous variants in NFKB2 typically cause immunodeficiency. Read these Clinical Insights on a novel NFKB2 variant w/hypertension & nephrotic syndrome leading to CKD 5D.
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Levamisole is a common steroid-sparing agent (SSA) but the incidence of antineutrophil cytoplasmic antibody (ANCA) positivity is concerning. Read this Original Article on children 2-18 y.o. w/FRNS/SDNS on levamisole for ≥1 year who were tested for ANCA.
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Lowe syndrome is characterized by congenital cataracts, psychomotor retardation & dysfunctional proximal renal tubules. Read this Original Article on atypical phenotypes & genetic characteristics of 8 children w/Lowe syndrome in southern China.
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Idiopathic nephrotic syndrome (INS) is the most common glomerular disease in children. Read this Original Article on histopathological findings, response to steroids & other immunosuppressive drugs, & outcomes in Syrian children w/INS.
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Studies indicate that pediatric IgA nephropathy (IgAN) might be different from adult IgAN, & treatment strategies might also be different. Read this Original Article on differences between children & adults with IgAN in 2 prospective cohorts. #OpenAccess
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Children w/CKD are at risk for vitamin deficiency or excess. Read these Guidelines from the Pediatric Renal Nutrition Taskforce on assessment & management of vitamin status in children w/CKD stages 2–5, on dialysis & post-transplantation. #OpenAccess
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Read this Research Letter on 3 children admitted w/pediatric acute glomerulonephritis (AGN) & pneumonia. The coexistence of pneumonia & AGN is not rare & all children w/coexisting acute pulmonary & kidney involvement should be carefully assessed & managed.
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Estimation of GFR identifies kidney disease, informs drug dosing & improves risk stratification. Read this Research Letter on differences between creatinine- & cystatin C-based eGFR in pediatric heart & liver transplant recipients before /after transplant.
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In pediatric kidney failure, native kidneys may pose a risk to successful transplant outcomes. Read this Review of indications for native nephrectomy & current knowledge gaps; plus, a surgical perspective re timing & approach. Free access this month.
bit.ly/43XLu1z

The importance of nutrition in the management of infants & children w/CKD has been recognized for decades, but achieving dietary aims has seemed almost insurmountable. Read this Editorial Commentary on gastrostomy feeding in children w/CKD.
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CKD is a set of conditions characterized by gradual loss of kidney function, & kidney failure is its last stage. Read this Editorial Commentary on the emerging role of clinical genetics in pediatric patients w/CKD.
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The Schwartz equation is the most widely used SCr-based formula to estimate GFR in children of European descent. Read this Original Article on using the SCr-based formula to estimate GFR in children in the Democratic Republic of Congo.
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Neonatal hypertension is common in preterm infants w/bronchopulmonary dysplasia (BPD). Read this Original Article on blood pressure variation in the first 3 months of life in preterm BPD patients. #OpenAccess
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