🧬💊 Through a collaboration with EVA, the Open Targets Platform recently brought in pharmacogenetics data from PharmGKB , adding a new dimension when prioritising targets for drug discovery

👇Read all about it

blog.opentargets.org/integrating-ph…

Have you see our new Direction of Effect assessments? 👀

Bioinformatician Juan María Roldán Romero walks you through this new feature of the Open Targets Platform

👇 Let us know what you think in the comments!

youtu.be/rvbttVwM4Dc

Postdoc positions 3 and 4 of our project with Open Targets have opened! If you are passionate for open-source data engineering using Large Language Models, and you like working in a world-leading professional environment, please check them out at opentargets.org/jobs

🧬💻 Generative AI has revolutionised the way we interact with knowledge — and we plan to leverage the advances in Large Language Model technology to extend the capabilities of the Open Targets Platform using open-source frameworks

Can you help?

#NowHiring #AIML

.MSD has joined the Open Targets consortium 👏

MSD's expertise in drug discovery will strengthen Open Targets' ambitious research programme, which aims to accelerate the identification and validation of novel drug targets.

ebi.ac.uk/about/news/ann…

One more week to apply! Come join us in Human Technopole if you are interested in B cell biology, CRISPR screens and immunogenomics.

LAST CHANCE!! Thanks for all who participated in our survey on effector/causal gene lists so far! If you haven't yet....we'd love to hear from you, especially if you *use* effector gene lists in your research or pipelines. Closing May 1st!

How and why was Open Targets founded?

Former Director Ian Dunham explains how discussions between Janet Thornton, Mike Stratton, and Patrick Vallance led to the founding of the Open Targets consortium (recorded in 2021)

CLOSING: Work on the largest dual CRISPR guide dataset to date — comprising 65,000 gene pairs across 2 tissue types and ~50 cell lines 🧬

👇 Take a look at 3 positions across EMBL-EBI and Sanger Careers collaborating on the analysis and validation of this unique dataset

Only a couple of days left! Pls apply if interested and RT!

Excited to share my first first-author paper, now live in Bioinformatics Advances! 📚 We assessed 31 cell-type deconvolution methods across five diverse tissues. 🧬academic.oup.com/bioinformatics…
#deconvolution #transcriptomics #singlecell

👷‍♀️🏗 The Open Targets team went to visit the construction site of the new Janet Thornton Building on the Wellcome Genome Campus Campus

The Thornton Building was designed around the key principles of collaboration, accessibility, and sustainability — we're looking forward to moving in!

An exciting time to join the project and make your mark on the discovery of new cancer targets!
Apply today to be part of this great team Open Targets Garnett Lab Evangelia Petsalaki

65K gene pairs screened across multiple cell lines, 2 tissues - data waiting for you to interpret and make important discoveries! collaboration with Open Targets Garnett Lab OT Validation lab and industry partners!

Out now in Annual Reviews!

We share our perspective on using human genetics for drug target identification, with examples from our work of the past 10 years, and our framework for building therapeutic hypotheses

#OpenTargetsat10

annualreviews.org/content/journa…

Out now! Together with members of our Exec & Science Leadership Team EMBL-EBI Wellcome Sanger Institute GSK Genentech Pfizer Inc. Bristol Myers Squibb Sanofi we share our perspective on how Open Targets we use human genetics & genomics for drug target ID & prioritisation: annualreviews.org/content/journa…

9 days left! Any questions feel free to DM or email me.

NEW: Experimental Oncology Technical Specialist with
Panos Zalmas

Validate therapeutic hypotheses that exploit synthetic lethality in cancer using the largest dataset to date of dual CRISPR perturbations

Closes 2 May

Sanger Careers

sanger.wd3.myworkdayjobs.com/en-US/Wellcome…

There is still time to voice your opinion on effector gene list generation/standards from GWAS data. This will inform the resources we build. A2FKP Common Metabolic Diseases Knowledge Portal GWAS Catalog Open Targets

Two Postdoc positions in my lab Human Technopole! Please RT!

We have an Open Targets project in collaboration with Gosia Trynka lab. An ambitious project, with industry partnership to comprehensively understand regulators of B cell activation using CRISPR screens.