Physiological stimulation of VTA dopamine neurons does not function as a reward and does not endow cues with a reward representations. But, high frequency stim is represented as a goal that motivates behavior.

Ivy Hoang Dr. Melissa Sharpe USYD Psychology UCLA

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A new study by UK DRI & Imperial Sciences researchers challenges a popular theory about why we sleep. Scientists found that clearance of toxins from the brain was actually reduced during sleep, rather than enhanced.

Read more in the The Guardian ⬇️
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Brain clearance is markedly reduced, not increased, during #sleep and #anesthesia in male mice

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Our May issue is now live!

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A remembrance of Bill Catterall

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A Perspective on assessing the contribution of the chemical #exposome to neurodegenerative disease

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Targeting pathological cells with #senolytic drugs reduces seizures in a model of neurodevelopmental mTOR-related #epilepsy (focal cortical dysplasia type II)

Stéphanie Baulac Institut du Cerveau - Paris Brain Institute Jean Christophe Poncer 🇪🇺

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A tool for unsupervised dimensionality reduction beyond neural subspaces with slice tensor component analysis (sliceTCA)

Heike Stein Cognition ENS School of Informatics, The University of Edinburgh École normale supérieure | PSL The University of Edinburgh

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Closed-loop recruitment of #striatal #interneurons prevents compulsive-like grooming behaviors in in male Sapap3 knockout mice

LizbethMG C Schreiweis Eric Burguiere NERB Team

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The layout of cortical systems varies across people, which is assumed to be largely due to border shifts between nearby systems. This work reveals a different variation in systems that occurs at a distance from expected locations

Caterina Gratton et al.

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In monkeys freely viewing natural images, #visual neurons from V1 to IT encode feature information in the gaze-centered space with limited predictive remapping and develop a neural network model to map the receptive fields

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Monkey prefrontal cortical circuits involved in action selection in a perceptual decision-making task are also used for the deliberation of of abstract propositions divorced from a specific motor plan

Julie Charlton Goris Lab.

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Unsupervised restoration of a complex learned behavior, song production, after large-scale neuronal perturbation causing severe song degradation in zebra finches

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A guide to science communication training for doctoral students

Christina Maher, Trevonn Gyles, Eric J. Nestler, MD, PhD & Daniela Schiller

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A conversation with Fernando de Castro Soubriet, who is among the group of Spanish scientists who ensured that the Archives of Santiago Ramón y Cajal and the Spanish Neurohistological School are registered as World Heritage with UNESCO 🏛️ #Education #Sciences #Culture 🇺🇳

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A remembrance of Larry Young

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Identification of two new components of human cortical gene expression architecture, C2 and C3, which are enriched for neuronal, metabolic and immune processes, specific cell types, and genetic variants

Richard Dear Ed Bullmore Petra Vertes

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A Comment on advancing the neuroscience of human #pregnancy from Magdalena Martínez-García PhD Emily G. Jacobs Ann-Marie de Lange Susana Carmona

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Mass cytometry identifies senescent, TREM2-expressing #microglia in #Alzheimer ’s disease model mouse brain that exhibit a distinct signature from TREM2-dependent disease-associated microglia (DAM)

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mRNA transport on lysosome-related vesicles is critical for the maintenance of axonal homeostasis and its failure causes axonal degeneration in human iPSC-derived and mouse neurons

Raffaella De Pace Saikat Ghosh Juan S. Bonifacino NICHD News

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