Thrilled to have our work on gnomAD out in print at Nature today. With 76K genomes, we can look beyond the coding genome and into the non-coding genome to find regions important for human disease nature.com/articles/s4158…

The eLife - the journal board has decided to fire the editor-in-chief for expressing his personal political opinion, in this case his concern about the bombing of civilians.

Excited to share our work introducing a remarkably efficient approach to model linkage disequilibrium, now published in Nature Genetics

nature.com/articles/s4158…

This work was led by Pouria Salehi Nowbandegani and Wilder Wohns

Out today nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo

📣We're hiring! Please RT and share. #postdoc position in statistical genetics at DBMI at Harvard Med. Salary above normal range.

Join O'Connor lab!! Working with Luke has been an amazing experience!

Recent literature suggests that unsupervised tissue region identification in spatial omics data requires complex statistical or graph neural network models.

However, in our new preprint, we introduce a much simpler approach: biorxiv.org/content/10.110…

My paper with Daniel Gilbert is out today in Nature: people believe that people are less kind than they used to be, they're probably wrong about that, and we have an idea where this illusion comes from. nature.com/articles/s4158…

The first new paper after our methods paper to use burden heritability regression. What a beautiful set of analyses and discoveries, congratulations!

Thank you to Dan Weiner and Ajay Nadig for presenting their groundbreaking research on the 'Polygenic architecture of rare coding variation across 394,783 exomes'. You can watch the complete talk here: tinyurl.com/5h6n7567
#genomics #bioinformatics #ComplexTraits

Mitochondrial DNA mutations can lead to rare disease and accrue with age. But how does nuclear genome variation influence mtDNA variation?

Here in >250k people, we find that nuclear variants can impact variation in the levels of mtDNA mutations. (1/5)

medrxiv.org/content/10.110…

thank you for the live-tweet Kaitlin Samocha !!

#ASHG22 Come see Ajay Nadig present 'Heritability and genetic architecture of rare coding variation across 394,000 exomes' today at 1:45 in West 515!

Preprint 👇
medrxiv.org/content/10.110…

Both common and rare genetic variants are relevant for autism.

But are they biologically convergent?

Today in Nature Genetics, we share a new method + story of unexpected convergence at 16p, a region of long-standing mystery in autism research:

nature.com/articles/s4158…

🧵 (1/14)