Please consider to attend ICCC2024 this summer. You can find all the conference programs by following this link (iccc2024.colostate.edu). The abstract submission is due on April 26.

The Penn State Bioinorganic Workshop will be offered from May 29 - June 4 - please see updates at sites.psu.edu/bioinorganic/2… with Dr. Jmb21 Squire J. Booker Joey Cotruvo Stoll Lab Sean Elliott Alex Guo H.S. Shafaat Tamra Blue Jarett Wilcoxen and many others

This is cool!

A Porphyrin Iron(III) pi-Dication Species and its Relevance in Catalyst Design for the Umpolung of Nucleophiles (Johannes E. M. N. Klein and co-workers) Silène Engbers, Alex Guo, Klein Lab, Stratingh Institute for Chemistry, CMU Chemistry #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

An S1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation (Yisong Guo and co-workers) NC State Chemistry Sean Elliott @BUChemisty BU Chemistry Alex Guo CMU Chemistry #AngewandteVIP #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Chemjobber We use internet-connected Raspberry Pis with cameras to monitor almost everything in the lab. Added benefit of remote access: You can  be disappointed about your reaction's performance 24/7

Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration (Chuo Chen and co-workers) Alex Guo CMU Chemistry @ncstatechem UTSW Graduate School of Biomedical Sciences #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

A recent study led by Chang NC State Chemistry and Chen UTSW Graduate School of Biomedical Sciences and joined by us Alex Guo CMU Chemistry discovered that Fe/2OG dependent enzymes are capable of catalyzing 2OG independent Mukaiyama hydration!
onlinelibrary.wiley.com/doi/10.1002/an…

Is the Fe(IV) intermediate in non-heme iron enzymes always in an S = 2 spin state? Answer is No. A collaborative study by Leland Gee, Chang NC State Chemistry, Sean Elliott and Liu BU Chemistry, and us CMU Chemistry revealed the first S = 1 Fe(IV) in non-heme catalysis. onlinelibrary.wiley.com/doi/abs/10.100…

We are getting ready to celebrate 40 years of Larry Que's career at UMN Department of Chemistry. Larry has mentored 150 researchers in this time. What an amazing career and I can't wait to hear more about #iron #enzymes and #catalysis in this party. #LQfest

We thank Chemical Science for featuring our recent collaborative work on a novel triplet Iron(IV)-Bisimido complex with Liang Deng and Ye Dalian Institute of Chemical Physics, CAS. The steric and electron-withdrawing nature of imido substituents enable unique chemical/physical and reactivity properties.

Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron #Enzymes by Lide Cha, Jared C. Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo Alex Guo at CMU Chemistry, and Wei-chen Chang at NC State Chemistry in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dihydroxylation Reactions Modeling Rieske Dioxygenases #Dihydroxylation #Mononuclear #Nonheme #IronPeroxo #Rieske #Mechansim pubs.acs.org/doi/10.1021/ja…

Please register to the virtual sessions to learn more about our diverse research programs.

Our website is officially live now! Check it out by clicking link below to find more about our symposium!
cmugsspc.org

Excited about this facility at CMU Mellon College of Science

Cloud labs: where robots do the research nature.com/articles/d4158…

Excited to share my lab’s first paper online today at Science. So proud of my team Jinyan Zhao Qun Anthony Huls Zhenhong Chen It was great fun to collaborate with Guo Group Alex Guo at CMU and Garcia-Borràs Group Marc Garcia Borràs at IQCC-UdG on this project! science.org/doi/10.1126/sc…

Congratulations, Kris!

A collaborative work led by the Chang group NC State Chemistry and joined by Alex Guo explores the mechanism of a methyl insertion reaction via cryptic oxidation, which expands the C-C bond formation mechanism in non-heme iron enzymes. J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Finally, someone explained the alchemical symbols on the elevator doors in the Mellon Institute CMU Mellon College of Science. Notice the handwritten one at the lower left corner? 🙊?