biophotonics in the brain is about to get a lot more attention. biorxiv.org/content/10.110…

Excited to share this perspective piece on mentoring that I wrote for Neuron with my grad school mentor, Greg Quirk! “Mentoring to propagate racial inclusivity in neuroscience” cell.com/neuron/abstrac…

The first piece of my PhD work is out in Neuropsychopharmacology! We explored the effects of infralimbic stimulation and protein synthesis inhibition during fear memory consolidation🧵 Steve Maren 🐀🧠💭😨 James Hassell Vitor Juliano et al. nature.com/articles/s4138…

Happy International Dog Day!

Looking back at some photos I took during my trip out to Wyoming and Utah with my dad after my thesis defense in 2022. Can’t believe it’s already been two years!

**Cooperative thalamocortical circuit mechanism for sensory prediction errors** Prediction errors via thalamic amplification! Seems like major result! And involves an old-time favorite, the pulvinar nucleus of the thalamus, an absolutely stunning region. doi.org/10.1038/s41586…

Bringing my account back to life just in time for #FluorescenceFriday with a peek at our preliminary dive into the human LC🔵in AD. Glials & microvessels surrounding tangles - let the adventure begin into their -omics! Major credit to Heena Divecha for the perfect slice!

VANDY ANCHORED DOWN THE UPSET W IN OVERTIME 😤 Vanderbilt Football

What a great day to be a Vanderbilt Commodore

Just dropped- a really epic work from Dr. Julia C Lemos and Larry Zweiffel, finally uncovering the functions of the enigmatic nucleus-accumbens CRH cells in reward behaviors. Unsurprisingly, this peptide's actions remain, ahem, WEIRD. sciencedirect.com/science/articl…

Exciting new paper exploring the intersection of aging and psychopathology. In Nature Neuroscience out of Binder Lab by Anna, focusing on the orbitofrontal cortex from NSW Brain Tissue Resource Centre 🇦🇺, an interesting but understudied area in the human brain nature.com/articles/s4159…

What happens when you use picrotoxin to stimulate the infralimbic cortex in🐀after fear conditioning?😱 Find out in this recent Neuropsychopharmacology paper from Hugo Bayer, Steve Maren 🐀🧠💭😨, & colleagues ⬇️ nature.com/articles/s4138…

Evidence for thyroid hormone regulation of amygdala-dependent fear-relevant memory and plasticity nature.com/articles/s4138…

New in Nature Neuroscience, we present DPAD, a deep learning method for dynamical modeling of neural-behavioral data & dissociating behaviorally relevant dynamics. It enables diverse neurotech & neuroscience use-cases. 👏Omid Sani 💻github.com/ShanechiLab/DP… 📜nature.com/articles/s4159… 🧵⬇️

Kontextual: Reframing analysis of spatial omics data reveals consistent cell relationships across images biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

It's in vivo clearing week: In Vivo Optical Clearing of Mammalian Brain biorxiv.org/content/10.110… Not with Clearitos but dextran-aCSF (and others)

A brain cell atlas integrating single-cell transcriptomes across human brain regions | Nature Medicine nature.com/articles/s4159…

Exciting opportunity! I am hiring a postdoc to join the group and to develop computational methods for the analysis of biomedical data including imaging and genomics data at a single-cell or spatial resolution 🧬 stephaniehicks.com/join

Come work with us! I genuinely couldn’t imagine a more supportive and exciting environment to do a postdoc 🧠🧬

#SpatialTranscriptomics Bin2cell reconstructs cells from high resolution #VisiumHD data 10x Genomics Transforming #VisiumHD 2-μm matrix into Single-Cell Spatial data StarDist segmentation (H&E Nuclei detection + expansion + fluorescence model-based salvage secondary