📢Registrations & abstract submission for the joint conference EpiGene3Sys x ChromDesign x INC-Spain now open! Visit chromdesign.eu/epic-conference for more info ⏳Deadline 31/5/22 @EpiGeneSysFP7 @INSB_CNRS ChromDesign Institut Curie Université PSL Centre for Genomic Regulation (CRG) Epigenetics Research at Helmholtz Munich Marie Skłodowska-Curie Actions

Thank you International Nucleome Consortium for the great conference and the opportunity to share my PhD project!

3 years, 4 in person meetings, exciting science, pushing boundaries, lots of fun and innumerable memories. Great mentors and best of friends. ChromDesign has been such a joyful ride! ME Torres-Padilla Marc A. Marti-Renom Kristian Helin @LucaGiorgetti @giacomo_cavalli Arun Kumar Sundaramurthy

Please retweet: Two PhD positions are available in my new lab at University of Zurich. Interested candidates can contact me directly or apply via the Life Science Zurich Graduate School. Application deadline December 1st 2022!

Now in Nature Genetics: Pia Mach, Pavel Kos in the lab of @LucaGiorgetti & colleagues shed light onto how the complex folds that help to fit nearly two meters of DNA into the cell’s nucleus influence important biological processes 👇🏿

📢Please RT: We're hiring two tenure-track group leaders, one in Multicellular Systems and one in Genome Regulation/Structural Biology. Apply by March 19 at: bit.ly/MulticellularS… or bit.ly/StructuralBiol… #AcademicTwitter

Happy to have contributed to the manuscript describing pairtools, the fundamental toolbox needed for analysis of #3DGenome 3C+ data, in particular for conversion of mapped reads to interpretable contacts! Third preprint by Open2C and it's always a pleasure to work together.

Looking forward to share my PhD project with the Fragile Nucleosome Community tomorrow!

How can we better understand the principles by which enhancers regulate their target promoters? @LucaGiorgetti and I reviewed new integrative approaches that address this question. Have a look here 👇 doi.org/10.1016/j.gde.…

The fantastic Fragile Nucleosome seminars from Pia Mach and @levine_lab are now up on our youtube! youtu.be/IF75lx_IKkc youtu.be/K0B2F1k6Pfo

(1/11) Check out our paper tinyurl.com/25wvf2v2 now out in Science Magazine on the role of cohesin-mediated loop extrusion in clustered Protocadherin expression and how that influences neural wiring patterns.

How do distant DNA loci come into contact to activate genes? Our paper combining live imaging 🔬& polymer physics 🧬 to answer this is out in Science Magazine! We show how chromosome packing & diffusion determine pairwise dynamics & transcription 👉science.org/doi/10.1126/sc… 1/n

Very happy to share the final version of our paper in NatureStructMolBiol, in which we show that the Mediator complex regulates enhancer-promoter interactions and Cohesin extrusion patterns: nature.com/articles/s4159…

Thank you to everyone for being there on Monday and for your support these past few years! Especially of course to @LucaGiorgetti and the entire Giorgetti lab! It was great fun with all of you and I am sad to see this time come to an end!

💥💥New pre-print alert 💥💥 👇 Xist RNA continues to fascinate: in our latest work we show that increased or decreased levels of Xist RNA directly control the expression levels of genes that escape X-inactivation 1/3 biorxiv.org/content/10.110…

New preprint by our lab -- Revealing the functional landscape of a large genomic locus by highly multiplexed local hopping of a reporter: biorxiv.org/content/10.110…. Even a 'simple' genomic locus such as the mouse Sox2 locus still holds surprises...

Have you ever wondered about how the genomic position of regulatory elements impact their functional output? Check out our latest pre-print from the @bvanssteensellab. biorxiv.org/content/10.110…

My lab is looking for PhD students with a background in physics and/or biochemistry/quantitative biology. If interested, please apply to the VBC graduate school. Deadline: Oct 15th.

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)