In collaboration with Geir Age Loset and team, latest paper from laboratory on #celiacdisease Monash Biomedicine Discovery Institute Monash University Science Immunology immunology.sciencemag.org/content/6/62/e…

We have generated TCR-like antibodies that bind gluten pMHC. The lead antibody prevents activation of gluten-specific T cells, suggesting a potential therapeutic strategy of celiac disease. Now out in Science Immunology! Great collab Geir Åge Løset @JCoDiRC Rossjohn lab Jeffrey J. Gray!

We just released CompAIRR – a tool that reduces greatly the longstanding computational bottleneck of identifying shared identical and similar sequences among large sets of immune repertoires. All the details/links are in the thread below. Feedback is very welcome! airr_community

I have an available 3-year #postdoc position in my lab in Oslo. Project on B cell-T cell interactions and the interplay between foreign and self-antigens in #autoimmunity. Read more and apply here 2411.webcruiter.no/Main2/Recruit/… @JCoDiRC @helsesorost UiO - Det medisinske fakultet

Happy to share our work on multi-dimensional comparison of immune repertoires. Amazing work by Cédric R Weber. Great collaboration with Xiao Liu, LSSI Reddy, Mariike Kuijjer, and, as always, Geir Kjetil Sandve. Main findings in 🧵. biorxiv.org/content/10.110….

Happy to share this story on anti-gluten antibodies in celiac disease. biorxiv.org/content/10.110… The project was led by Chunyan Zhou @JCoDiRC UiO - Det medisinske fakultet and is the result of a long-standing collaboration with the Buus lab University of Copenhagen. Main findings are summarized below.

We used scRNA-seq to assess the combined transcriptome and Ig repertoires of CSF B cells in MS. This revealed a stereotyped B-cell response using IGHV4/IGKV1 in patients carrying certain IGHC alleles! European Journal of Immunology #MS onlinelibrary.wiley.com/share/author/G…

IgG3’s hinge packs a punch! 🥊 We are excited to share our latest work published in Science Immunology, based on a very fruitful collaboration with the lab of Leo James at @MRC_LMB. @RCN_Norway @helsesorost UiO - Det medisinske fakultet Oslounivsykehus @UiO_LifeSci science.org/doi/10.1126/sc…

New article alert! Geir Åge Løset (Department of Biosciences, University of Oslo), in collaboration with Jeffrey J. Gray, show how structural models and phage display enable the generation of TCR-like antibodies with picomolar affinities. academic.oup.com/peds/advance-a…

Happy to share our latest work! Generation of high-affinity TCR-like antibodies by use of phage display and structural models Rahel Frick Geir Åge Løset Jeffrey J. Gray @JCoDiRC

We are still learning 🔬Torleif Tollefsrud Gjølberg Rahel Frick Simone Mester @stianfo1982 Lene Støkken Høydahl and colleagues give a fascinating glimpse into antibody biology & the complexity of design Norges forskningsråd Roche Deutschland UiO - Det medisinske fakultet Forskningsparken - Oslo Science Park The Antibody Society nature.com/articles/s4200…

Our perspective on antibody formation to gut bacteria is now out Nature Reviews Gastroenterology & Hepatology. Shared effort with Ludvig Sollid @JCoDiRC. In our view, T cells are crucial regulators of anti-bacterial antibodies. Check it out here rdcu.be/cUQKa

If you want to get up to date on celiac disease pathogenesis, check out our latest review Annual Reviews. Another shared effort with Ludvig Sollid. annualreviews.org/doi/abs/10.114…

Very happy to share that our paper on anti-gluten antibodies in celiac disease is out now in Cell Reports. The study was led by Chunyan Zhou @JCoDiRC UiO - Det medisinske fakultet and was a great collaboration with the Buus lab UCPH Healthscience. Details in 🧵 cell.com/cell-reports/f…

Very happy to share this story on autoreactive B cells in celiac disease together with Ida Lindeman Lene Støkken Høydahl Asbjørn Christophersen Louise Fremgaard Risnes @JCoDiRC. Here, we identify a population of circulating IgA-switched B cells specific to the self-antigen transglutaminase 2 (TG2).

I am so happy to share that our study has been published today in nature ! 🎉This has been an absolutely fantastic teamwork between Dr Emily Thornton, Yisu Gu The Powrie Lab and Teichlab [Link: rdcu.be/dDzwx]

Our paper on circulating autoreactive B cells in celiac disease is now out in Cell Reports 🎉. Big thanks to everyone involved! cell.com/cell-reports/f…

Happy to share this story on autoreactive naive B cells of relevance to celiac disease. Out now in the Journal of Autoimmunity. More details in 🧵 sciencedirect.com/science/articl…

I'm excited to share that our latest research on celiac disease and gluten-specific T cells is now published in the July issue of Gastroenterology! 🌟 #CeliacDisease #Gastroenterology #Gluten Asbjørn Christophersen @JCoDiRC Knut E A Lundin 🌾👩‍🔬

Very excited to share our paper on enzyme-activating BCRs and their role in gluten-sensitive autoimmunity! rdcu.be/ecXfG bsky.app/profile/rasmus…