The liver can be a path towards establishing immune tolerance for autoimmune diseases. But it also promotes immune evasion of cancer. A mechanism for this is identified here and could prove useful for directing therapy
nature.com/articles/s4159…
Nature Immunology Beatty Lab Penn Medicine

“Maybe I should give it as an analogy… IDK, I have been thinking about dogs lately. Maybe it bifurcated into a frenchie or shorkie… Like a shih tzu and a Yorkie.”

#shitgregorysays

Happy Solar Eclipse Day!🌘

For anyone that missed the eclipse or didn’t have eye protection to view it, enjoy these pics our newest undergrads were able to capture:

“When you leave the house you never leave the home Jesse Lee “

#ShitGregorySays

“It's not as fun as flipping it on, flipping it off, flipping it on, flipping it off, flipping it on, flipping it off, flipping it on, flipping it off, flipping it on, flipping it off, like a light switch”💡-Gregory Beatty
#ShitGregorySays

“We hope to provide a roadmap to overcome the barriers that prevent #immunotherapy from penetrating throughout the tumor microenvironment and attacking #cancer cells,” said Dr. Gregory Beatty, on his work to improve immunotherapy for #PancreaticCancer . spr.ly/6018Xvy68

Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice ft. Stacy Thomas, Max Wattenberg, Shaanti Choi-Bose, Heather Coho, Christopher Cassella, Meredith Stone, Dhruv Patel, Kelly Markowitz, Devora Delman & Beatty Lab tinyurl.com/mrytyyyz

Here's some insight from Max Wattenberg's on his latest work in Science Immunology which found a potential approach to improve immunotherapy in #pancreaticancer . Penn Medicine - Abramson Cancer Center Beatty Lab acir.org/weekly-digests…

Targeting CD40 and Dectin-1 in tumoral macrophages in pancreatic cancer. Read our digest and interview with Max Wattenberg here 👉 bit.ly/3RkQVCF  Univ. of Pennsylvania Department of Cancer Biology  Beatty Lab

Whoooo we're done!! And with that...I will soon be handing the control of this twitter to yet another mischievous Beatty Lab member. It's been a pleasure memeing with you all the last couple of years, and hopefully I'll meet you out there in the field!
Best,
(Dr.) Jesse Lee

Jesse Lee from the Beatty Lab defends tomorrow!
Beatty Lab

#OpenAccess in Science Immunology from Beatty Lab Max Wattenberg
Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
science.org/doi/10.1126/sc…
How to co-opt the anti-tumor functions of myeloid cells in #PancreaticCancer through complementary pathways.

What's this? Is it a bird? Is it a plane? No!! It's Max Wattenberg's work hot off the (digital) presses!

He took some myeloid treatment and some other myeloid treatment thingy...something something...cured cancer...through some mechanism. Go read it NOW!!

science.org/doi/10.1126/sc…

Combining two treatments that activate myeloid cells may prove successful against tumors where conventional T cell-based immunotherapies have failed, indicates new research in mouse models of pancreatic cancer. Max Wattenberg Beatty Lab Penn Medicine

📄: scim.ag/4RU

Its World Pancreatic Cancer Day!! We out here turning the world purple! PanCAN #PanCANawareness .

Look at the pretty cake from instagram.com/sprinklesitali…!

Cancer research makes the impossible possible:
Emily Whitehead was the first child cured of cancer with therapy from Penn. She’s back as a freshman.
Penn PennMedicine Children's Hospital #immunotherapy
inquirer.com/health/leukemi…

New number who dis?

Anyone ever wonder what their PI says in talks? We wonder...🤔🤔🤔

Nice preclinical work from Beatty Lab
Kupffer cells prevent #PancreaticCancer metastasis to the liver in mice
nature.com/articles/s4146…

Hooray it's out!! The work of our (now graduated) star graduate student Stacy Thomas is out!

nature.com/articles/s4146…

When asked to comment, she said... 'sure'. Now how bout that?! Even more reason to check out her work!!