Overly complex methods may impair pragmatic use of core evidence-based medicine principles

#Editorial by Rebecca Kuehn, Ying Wang, Gordon H. Guyatt

Highlight of the EBHC Conference 2023

Link: bit.ly/4aNWGzR

Two articles highlight big problems when platform trials include non-contemporaneous controls. In addressing A vs no A, analysis should only use randomizations that included possibility of A. Should never use controls of B vs non-B.
nejm.org/doi/full/10.10…
sciencedirect.com/science/articl…

Long anticipated, it's here now

🌐 Exploring the frontier of #DigitalBiomarkers in #healthcare ! Learn how devices like smartphones and wearables are revolutionizing #healthdata collection.

Link to Article: bit.ly/4cWkJhM

Tim Woelfle Lars G. Hemkens #healthtech #smartdevices #wearabledevices

Ioannidis JPA.
Leading researchers in the leadership of leading research universities: meta-research analysis.
bioRxiv 2024.04.02.587840; doi: doi.org/10.1101/2024.0…. biorxiv.org/content/10.110…

Do elements with rounded shapes enhance click-through rates?
Maybe; the two controlled experiments that supposedly justify this claim are not trustworthy. A fun exercise is to see if you can identify why the two A/B tests in the paper are flawed, just from the relevant paragraphs…

Data Checks Before Registering Study Protocols for Health Care Database Analyses. A very interesting JAMA viewpoint:

jamanetwork.com/journals/jama/…

A new #RC2NB study in BMJ Health Care & Informatics explores digital biomarkers. There is no consensus in the field, with 127 out of 128 articles providing different definitions. The study aims to guide the development of a more widely accepted definition. informatics.bmj.com/content/31/1/e…

We found in 128 studies 127 definitions of 'digital biomarker'.

Consensus needed to facilitate use of this promising technology !!

RC2NB BMJ Health & Care Informatics

informatics.bmj.com/content/31/1/e…

Voting for death?
The Swiss were the only people in the world voting on public health measures to control COVID-19.
We estimated excess mortality at the municipal level for the year 2020 in Switzerland.
tinyurl.com/mwstuj58
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Great example of importance to consider socio-economic factors for real-world evidence studies!

Just imagine interpretation without having that data.

This is fun

Isn’t that exactly what makes 'usual care' usual? Unfortunately, in real world, care is rarely optimal, so it would be totally artificial if care would be optimal or standardized everywhere, no?

Justification for unequal allocation ratios in clinical trials
sciencedirect.com/science/articl…

New paper out 📢: 'When evidence changes: communicating uncertainty protects against a loss of trust.' Read the paper here journals.sagepub.com/doi/10.1177/09… (1/4)

Workshop: How can your institution ensure that all #clinicaltrials are registered?

21 March at 14:00 CET

Please RT and share with all research governance / CTU people you know.

Sign up here (it's free):
eventbrite.co.uk/e/make-it-publ…

Recent important, useful innovation in conducting and presenting the results of subgroup analysis. Should become standard procedures. doi.org/10.1002/jrsm.1…

Flu vaccine is one of our most efficient cardiovascular drugs

This is the greatest randomized controlled trial joke ever told

We followed up trials registered on clinicaltrials.gov and the EU clinical trials registry, which were completed 2016-2019 and sponsored by a Nordic medical university or university hospital.

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