I might have missed this paper but can someone please point me to the evidence where tPA saves lives?
#misleading

Manrique Umana McDermott 😂😂😂 you're gonna bring all the neurologists out of their nests to yell at you. The studies are terrible that there's any significant benefit unless you're dealing with a clot with penumbra but they love it so much.

Eugene 🇺🇦 Puneet Gupta Manrique Umana McDermott Generally agreed that the NINDS trial had unbalanced groups favouring tPA group. This was thought to be due to random chance. Neurologist Ravi published an analysis with concerns about the fidelity of the randomization. pubmed.ncbi.nlm.nih.gov/35705913/

Eugene 🇺🇦 Puneet Gupta Manrique Umana McDermott Ravi Then there are the issues with ECASS-3 identified by Brian S. Alper, MD, MSPH, FAAFP, FAMIA in his publication in BMJ Evidence-Based Medicine

ebm.bmj.com/content/25/5/1…

Eugene 🇺🇦 Puneet Gupta Manrique Umana McDermott Ravi Brian S. Alper, MD, MSPH, FAAFP, FAMIA BMJ Evidence-Based Medicine Prof Fatovich from Centre for Clinical Research in Emergency Medicine wrote this editorial after IST-3 was published. onlinelibrary.wiley.com/doi/10.1111/j.…

Eugene 🇺🇦 Puneet Gupta Manrique Umana McDermott Ravi Brian S. Alper, MD, MSPH, FAAFP, FAMIA BMJ Evidence-Based Medicine Centre for Clinical Research in Emergency Medicine Stroke neurologist and colleagues wrote this about their ethical concerns in stroke thrombolysis onlinelibrary.wiley.com/doi/10.1111/an…

Ken Milne MD Eugene 🇺🇦 Manrique Umana McDermott Ravi Brian S. Alper, MD, MSPH, FAAFP, FAMIA BMJ Evidence-Based Medicine Centre for Clinical Research in Emergency Medicine Tell that to the critical care neurologist that almost took my life for besmirching the honor of tPA. May it reign in its vialy magnificence 😂😂

Ken Milne MD Eugene 🇺🇦 Manrique Umana McDermott Ravi Brian S. Alper, MD, MSPH, FAAFP, FAMIA BMJ Evidence-Based Medicine Centre for Clinical Research in Emergency Medicine I forgot about this gem