Three years in the making! onlinelibrary.wiley.com/doi/10.1002/hb…
4 reasons why you should read our new paper on the genetics of brain morphometry: ⬇️🤓

Cajal y los cargos.

'En España muchos parecen ocupar un puesto no para desempeñarlo, sino para cobrarlo y tener, de paso, el gusto de excluir a los aptos'.

gptstudio, a way to integrate #chatGPT into #RStudio , is my first R package on CRAN! It started as my holiday project but blew up I am just a scientist not a dev, luckily James Wade stepped in, and made it way much better! He is the #1 maintainer now. cran.r-project.org/web/packages/g…

Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis

Kudos to Andrew Grotzinger Travis Mallard Zhaowen Liu Tian Ge Jakob Seidlitz

rdcu.be/c6hpy

Discovering the genetic roots of diseases just got easier!
Our study sheds new light on the heritability and pleiotropy shared across diseases using a novel method that can scale to millions of individuals.
#heritability CPRatUCPH
medrxiv.org/content/10.110…

So excited to share our work on the genetic architecture of rare coding variation, now published in nature

nature.com/articles/s4158…

This work was led by superstar co-first authors Dan Weiner and Ajay Nadig

R01 submitted, mission accomplished.

Check out our new review of molecular mechanisms as pathways linking environmental exposures to chronic diseases in the latest issue of Nature Reviews Genetics! Andrea Baccarelli Haotian (Howie) Wu Nature Reviews Genetics

nature.com/articles/s4157…

See you tomorrow at Javier de la Fuente exciting talk at Max Planck Institute for Human Development on the genetic architecture of health and aging 🧬🧓⚕️ !!

You are cordially invited to this hybrid event co-hosted by the MPRG Biosocial and Center for Lifespan Psychology (MPIB, Berlin)

⏰⏲️24 Jan, 1 pm
Digital access via: mpib-berlin.webex.com/mpib-berlin/j.…

Excited about next week's talk at Max Planck Institute for Human Development. I will be talking about Genomic SEM, multimorbidity, and geroscience!

EWAS of 14 prevalent and 19 incident disease states in up to 18,413 volunteers (w/ 14 years of follow-up) from Generation Scotland. Plus comparison with existing findings from the literature.

Robert Hillary's latest pre-print now out.

medrxiv.org/content/10.110…

So excited to present an overview of my ongoing project on the genetics of multimorbidity and aging at Max Planck Institute for Human Development. See y'all on Jan 24th in Berlin!

Humans are the only bipedal great apes, due to our unique skeletal form. What genomic regions contributed to such change? Our work, combining imaging, genetic & EHR data to understand the genetic architecture and evolution of the human skeletal form is up: biorxiv.org/content/10.110…

Our commentary is now published Age_and_Ageing on genomics and multimorbidity academic.oup.com/ageing/article… 👀 not just for people who understand genetics already but looking to the future GEMINI University of Exeter Faculty of Health & Life Sci Tim Frayling Luke Pilling

Check out our new paper introducing the Transcriptome-wide Structural Equation Modeling (T-SEM) extension of Genomic SEM! T-SEM is a multivariate equivalent of TWAS for examining the effect of imputed gene expression across genetically correlated traits:
rdcu.be/cX1Hm

Alcázar de Segovia, principios del siglo XII. Fortaleza real de los Reyes de Castilla.

de la Fuente et al estimate liability-scale SNP heritability of #Alzheimers Disease outside the APOE region >2x recent estimates

Javier de la Fuente Andrew Grotzinger MarioniGroup Michel Nivard Elliot Tucker-Drob UT Psychology The Center for Aging and Population Sciences #Genetics #Genomics #Alzheimers
doi.org/10.1371/journa…

Time to take a look and curate some sumstats