Javier de la Fuente(@Dr_delaFuente) 's Twitter Profileg
Javier de la Fuente

@Dr_delaFuente

Research Associate @UTAustin | Life course epidemiology | Genomics | Individual Differences |

ID:1009007280191361025

calendar_today19-06-2018 09:37:36

280 Tweets

239 Followers

497 Following

Andrew Grotzinger(@Andrew_Grotz) 's Twitter Profile Photo

Check out our new paper introducing the Transcriptome-wide Structural Equation Modeling (T-SEM) extension of Genomic SEM! T-SEM is a multivariate equivalent of TWAS for examining the effect of imputed gene expression across genetically correlated traits:
rdcu.be/cX1Hm

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Javier de la Fuente(@Dr_delaFuente) 's Twitter Profile Photo

I’m eating fried catfish drinking a shiner bock listening Hank Williams III in a Texas one-horse town. This is amazing.

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Mike Inouye(@minouye271) 's Twitter Profile Photo

What are the effects of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’)? nature.com/articles/s4159…

New paper from Andrea ganna and co looks at common and rare variants, and polygenic scores.

What are the effects of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’)? nature.com/articles/s4159… New paper from @andganna and co looks at common and rare variants, and polygenic scores.
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IBG(@IBG_CUBoulder) 's Twitter Profile Photo

Check out this new work from IBG faculty member Andrew Grotzinger and co-authors Javier de la Fuente, Florian Privé, Michel Nivard, and Elliot Tucker-Drob, describing both a downward bias in liability scale h2 estimates using standard practices and a simple solution. 📰🧬🚨
(authors.elsevier.com/c/1faKv1S07mVlk)

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Daniel Belsky(@Danbelsky) 's Twitter Profile Photo

Great new work lead by ⁦Megan (Breitbach) Ramaker⁩ in the Trial. Genome-wide analysis of DNA methylation changes in response to 2y of calorie restriction in healthy, non-obese humans. 1/ academic.oup.com/biomedgerontol…

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Ted Schwaba(@Tedo_) 's Twitter Profile Photo

We're launching the Revived Genetics of Personality Consortium to study the molecular genetics of the Big Five, and we're looking for co-founders! If you're involved with a study that has collected GWAS & personality data, come fill out this questionnaire: tinyurl.com/mryrwh88

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Nature Aging(@NatureAging) 's Twitter Profile Photo

✨RESEARCH: Study shows sST2 is a disease-causing factor in AD, impairs microglial Aβ clearance in APOE4+ female individuals. A genetic variant of sST2, rs1921622, protects against AD in APOE4+ female individuals rdcu.be/cRLzU 🔓 doi.org/10.1038/s43587…

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Celso Arango(@CALDirector) 's Twitter Profile Photo

En el Ministerio figuraban incompetentes consejeros,…sin más objeto que cobrar pingües dietas…a quienes les importa una higa que una Cátedra de Madrid recaiga en un sabio, en un inepto o en un vividor. Santiago Ramón y Cajal el 25 de mayo de 1919.

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Travis Mallard(@wakeworksleep) 's Twitter Profile Photo

Well, well, well ... Look who finally showed up … Our study on genetic risk for mood and psychotic psychopathology is now published in Cell Genomics! 🧬🧠👨‍💻 cell.com/cell-genomics/…

I’m excited to see this one in print. A few highlights:

Well, well, well ... Look who finally showed up … Our study on genetic risk for mood and psychotic psychopathology is now published in Cell Genomics! 🧬🧠👨‍💻 cell.com/cell-genomics/… I’m excited to see this one in print. A few highlights:
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Javier de la Fuente(@Dr_delaFuente) 's Twitter Profile Photo

Our novel multivariate method is implemented in Genomic SEM. A tutorial for the method can be found here: github.com/GenomicSEM/Gen…. I will be happy to provide guidance to anyone interested in applying the method 9/10

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Javier de la Fuente(@Dr_delaFuente) 's Twitter Profile Photo

Altogether our results suggest the genetic risk of AD is characterized by core pathways (APOE) superimposed upon a diffuse but highly polygenic background that accumulates continuously across the entirety of the genome. 8/10

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