Marcin Czerwinski
@CzerwinsMarcin
Researcher | glycobiology | blood groups | Hirszfeld Institute of Immunology and Experimental Therapy | enviroment | photography | views my own
ID:3168807611
https://www.researchgate.net/profile/Marcin_Czerwinski 15-04-2015 07:02:07
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Compound heterozygosity for GYPC exon 2 (GE*01.-02) and exon 3 (GE*01.-03) in the donor and her sister. Anti-Ge2 antibody present (probably naturally occuring). tinyurl.com/5a26su4z
#blood_groups
SIDT1/SIDT2 proteins mediate the cellular uptake and intracellular trafficking of nucleic acids: 8 potential N-glycosylation sites, 5 of them active, required to enter the Golgi. Removal of N-glycans disrupts the interaction with RNA. Journal of Biological Chemistry tinyurl.com/ujrc7byu
#glycotime
Aleksandra Kołodziejczyk Aleksandra (Ola) Kolodziejczyk and Ewelina Malecka have been awarded EMBO Installation Grants. Congratulations to all laureates!
#LifeSciences #ResearchFunding
Interesting! HPV infection: myosin-9 (NMHC-IIA) interacts with HPV L1 protein and mediates HPV internalization. N-glycans, esp. with terminal Gal, may act as the decoy receptors for HPV by blocking the interaction of HPV to myosin-9. Journal of Biological Chemistry tinyurl.com/539kpyke
#glycotime
Excited to share Kelli's major PhD work where we dissected the ability of Siglecs to regulate Fc(gamma) receptors, published in ACS Central Science . Thank you to collaborators Peng Wu, Amanda Gavin, and Wayne Poon. pubs.acs.org/doi/10.1021/ac…
Our article 'Myriad applications of bacteriophages beyond phage therapy' was one of the top 5 most viewed #Biotechnology #EnvironmentalContaminationRemediation #Microbiology and #Virology articles published in PeerJ - the Journal of Life & Environment journal in 2023! peerj.com/articles/15272/
FacMed con F de Fagos
2 N-glycosylation sites in CD14, a co-receptor for LPS: at N151, a complex N-glycan pointing outside the protein surface and recognized byl galecin-4. At N282, unprocessed oligoMan not accessible to glycosidases, fundamental for protein folding.
tinyurl.com/mu5sesx6
#glycotime
CAR-T cell therapy in lung cancer: treatment of CAR-Ts with 2-deoxy-glucose causes reduced binding of immune-inhibitory molecules by blocking N-glycosylation of their receptors, so CAR-Ts can survive in the suppressive tumor microenvironment. tinyurl.com/9wykjv8w
#glycotime
New preprint alert! With physicist colleagues in Toulouse, Siewert-Jan Marrink and Weria Pezeshkian we propose a methodological strategy to link nano and meso models to study curvature based lipid domains formation at different scales
arxiv.org/abs/2401.05785
Tools for investigating O-GlcNAc in biological pathways: MS, metabolic labeling, RNA aptamers, FRET, proximity labeling, nanobody-directed and light-activated OGT/OGA tools, inhibition/chemoenzymatic studies, nutrient reporter assays Journal of Biological Chemistry tinyurl.com/ymhuzhpu
#glycotime
Regulation of protein O-GlcNAcylation by circadian, metabolic and cellular signals Journal of Biological Chemistry tinyurl.com/25278uhs
#glycotime